Selectivity of a bromoacridine-containing fluorophore for triplex DNA

Sharma, Sanjeev and Fraser, William (2021). Selectivity of a bromoacridine-containing fluorophore for triplex DNA. Monatshefte für Chemier, 152 (8), pp. 1013-1016.

Abstract

Fluorophore 1,8-naphthilamide was linked to 2-bromoacridine through an ethylenediamine spacer using a succinct synthetic route to give a bromoacridine-linked bifunctional fluorophore conjugate for the detection of triplex DNA. Acridine is well known to intercalate into duplex DNA whereas introduction of a bulky bromine atom at position C2 redirects specificity for triplex over duplex DNA. In this work, photoelectron transfer assay was used to demonstrate that the synthesised 2-bromoacridine-linked fluorophore conjugate had good selectivity for the representative triplex DNA target sequence d(T*A.T)20 compared with double-stranded d(T.A)20, single-stranded dT20 or d(G/A)19 DNA sequences.

Publication DOI:	https://doi.org/10.1007/s00706-021-02816-5
Divisions:	College of Health & Life Sciences > Aston Pharmacy School College of Health & Life Sciences
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Uncontrolled Keywords:	Bisensors,Fluorescence spectroscopy,Heterocycles,Nucleic acids,General Chemistry
Publication ISSN:	1434-4475
Last Modified:	22 Nov 2024 08:17
Date Deposited:	07 Jul 2021 11:13
Full Text Link:
Related URLs:	http://www.scop ... tnerID=8YFLogxK (Scopus URL) https://link.sp ... 706-021-02816-5 (Publisher URL)
PURE Output Type:	Article
Published Date:	2021-08
Published Online Date:	2021-08-07
Accepted Date:	2021-07-05
Authors:	Sharma, Sanjeev Fraser, William ( 0000-0001-6588-0166)