Kalaiselvan, Parthasarathi, Konda, Nagaraju, Pampi, Nending, Vaddavalli, Pravin Krishna, Sharma, Savitri, Stapleton, Fiona, Kumar, Naresh, Willcox, Mark D. P. and Dutta, Debarun (2021). Effect of Antimicrobial Contact Lenses on Corneal Infiltrative Events:A Randomized Clinical Trial. Translational Vision Science & Technology, 10 (7),
Abstract
Purpose: To determine whether Mel4-coated antimicrobial contact lenses (MACLs) can reduce the incidence of corneal infiltrative events (CIEs) during extended wear. Methods: A prospective, randomized, double-masked, single-center, contralateral, extended contact lens wear clinical trial was conducted with 176 subjects. Each participant was randomly assigned to wear a MACL in one eye and an uncoated control contact lens in the contralateral eye or an extended-wear biweekly disposable modality for 3 months. The main outcome measures were the incidence of CIEs per 100 eye-months, identification of the microbial types colonizing the contact lenses or eyes at the time of the CIEs, and their susceptibility to Mel4. Results: Nine participants (5.1%) experienced unilateral CIEs; six participants had contact lens acute red eye, and three participants had infiltrative keratitis. The incidence rate for CIEs (0.4 events per 100 participant months; 1.7%) in the Mel4-coated lenses (test) was 69% less than that of the control lenses (1.3 events per 100 participant months; 3.4%; P = 0.29). All Gram-negative bacteria isolated from lenses and lids of participants with CIEs (Citrobacter diversus, Acinetobacter haemolyticus, and Acinetobacter lwoffii) were susceptible to Mel4 peptide; minimum inhibitory concentrations ranged from 15.6 to 62.5 µg/mL. Reduction of adhesion of these bacteria by Mel4-coated lenses ranged from 2.1 to 2.2 log10 colony-forming units/lens. Conclusions: MACLs had the capacity to reduce CIEs by at least 50% compared with uncoated control lenses during extended wear over 3 months; however, due to the relatively low rates of CIEs, the reduction was not statistically different compared with control lenses. Translational Relevance: This study provides evidence that antimicrobial contact lenses have the potential to reduce the incidence of corneal infiltrative events during extended wear.
Publication DOI: | https://doi.org/10.1167/tvst.10.7.32 |
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Divisions: | College of Health & Life Sciences > School of Optometry > Optometry College of Health & Life Sciences > School of Optometry > Optometry & Vision Science Research Group (OVSRG) College of Health & Life Sciences |
Additional Information: | Copyright 2021, The Authors. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. Funding: Supported by a National Health and Medical Research Council development grant (APP1076206), by the Hyderabad Eye Research Foundation, and by CooperVision, Inc. |
Uncontrolled Keywords: | Antimicrobial peptide,Mel4 peptide,antimicrobial contact lenses,corneal infiltrative events,clinical trial,Antimicrobial contact lenses,Corneal infiltrative events,Clinical trial,Ophthalmology,Biomedical Engineering |
Publication ISSN: | 2164-2591 |
Last Modified: | 09 Dec 2024 08:38 |
Date Deposited: | 05 Jul 2021 08:23 |
Full Text Link: | |
Related URLs: |
https://tvst.ar ... ticleid=2776419
(Publisher URL) http://www.scop ... tnerID=8YFLogxK (Scopus URL) |
PURE Output Type: | Article |
Published Date: | 2021-06-30 |
Accepted Date: | 2021-05-10 |
Authors: |
Kalaiselvan, Parthasarathi
Konda, Nagaraju Pampi, Nending Vaddavalli, Pravin Krishna Sharma, Savitri Stapleton, Fiona Kumar, Naresh Willcox, Mark D. P. Dutta, Debarun ( 0000-0002-2204-5272) |
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