Effect of Antimicrobial Contact Lenses on Corneal Infiltrative Events:A Randomized Clinical Trial

Abstract

Purpose: To determine whether Mel4-coated antimicrobial contact lenses (MACLs) can reduce the incidence of corneal infiltrative events (CIEs) during extended wear. Methods: A prospective, randomized, double-masked, single-center, contralateral, extended contact lens wear clinical trial was conducted with 176 subjects. Each participant was randomly assigned to wear a MACL in one eye and an uncoated control contact lens in the contralateral eye or an extended-wear biweekly disposable modality for 3 months. The main outcome measures were the incidence of CIEs per 100 eye-months, identification of the microbial types colonizing the contact lenses or eyes at the time of the CIEs, and their susceptibility to Mel4. Results: Nine participants (5.1%) experienced unilateral CIEs; six participants had contact lens acute red eye, and three participants had infiltrative keratitis. The incidence rate for CIEs (0.4 events per 100 participant months; 1.7%) in the Mel4-coated lenses (test) was 69% less than that of the control lenses (1.3 events per 100 participant months; 3.4%; P = 0.29). All Gram-negative bacteria isolated from lenses and lids of participants with CIEs (Citrobacter diversus, Acinetobacter haemolyticus, and Acinetobacter lwoffii) were susceptible to Mel4 peptide; minimum inhibitory concentrations ranged from 15.6 to 62.5 µg/mL. Reduction of adhesion of these bacteria by Mel4-coated lenses ranged from 2.1 to 2.2 log10 colony-forming units/lens. Conclusions: MACLs had the capacity to reduce CIEs by at least 50% compared with uncoated control lenses during extended wear over 3 months; however, due to the relatively low rates of CIEs, the reduction was not statistically different compared with control lenses. Translational Relevance: This study provides evidence that antimicrobial contact lenses have the potential to reduce the incidence of corneal infiltrative events during extended wear.

Publication DOI: https://doi.org/10.1167/tvst.10.7.32
Divisions: College of Health & Life Sciences > School of Optometry
College of Health & Life Sciences > Ophthalmic Research Group
College of Health & Life Sciences
Additional Information: Copyright 2021, The Authors. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. Funding: Supported by a National Health and Medical Research Council development grant (APP1076206), by the Hyderabad Eye Research Foundation, and by CooperVision, Inc.
Uncontrolled Keywords: Antimicrobial peptide,Mel4 peptide,antimicrobial contact lenses,corneal infiltrative events,clinical trial,Antimicrobial contact lenses,Corneal infiltrative events,Clinical trial,Ophthalmology,Biomedical Engineering
Full Text Link:
Related URLs: https://tvst.ar ... ticleid=2776419 (Publisher URL)
http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2021-06-30
Accepted Date: 2021-05-10
Authors: Kalaiselvan, Parthasarathi
Konda, Nagaraju
Pampi, Nending
Vaddavalli, Pravin Krishna
Sharma, Savitri
Stapleton, Fiona
Kumar, Naresh
Willcox, Mark D. P.
Dutta, Debarun (ORCID Profile 0000-0002-2204-5272)

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