Evaluation of the effectiveness and acceptability of intramuscular clozapine injection:illustrative case series


Aims and method: A series of eleven patients prescribed intramuscular clozapine at five UK sites is presented. Using routinely collected clinical data, we describe the use, efficacy and safety of this treatment modality. Results: We administered 188 doses of intramuscular clozapine to eight patients. The remaining three patients accepted oral medication. With the exception of minor injection site pain and nodules, side-effects were as expected with oral clozapine, and there were no serious untoward events. Nine patients were successfully established on oral clozapine with significant improvement in their clinical presentations. Clinical implications: Although a novel formulation in the UK, we have shown that intramuscular clozapine can be used safely and effectively when the oral route is initially refused.

Publication DOI: https://doi.org/10.1192/bjb.2020.6
Divisions: College of Health & Life Sciences
College of Health & Life Sciences > Aston Pharmacy School
Additional Information: Copyright © The Authors 2020. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Uncontrolled Keywords: Clozapine,intramuscular,schizophrenia,treatment refusal
Publication ISSN: 2056-4708
Last Modified: 27 Jun 2024 10:46
Date Deposited: 03 Jun 2021 13:06
Full Text Link:
Related URLs: https://www.cam ... 25097D572A0FB45 (Publisher URL)
PURE Output Type: Article
Published Date: 2020-02-21
Accepted Date: 2020-01-17
Authors: Henry, Rebecca
Massey, Ruth
Morgan, Kathy
Deeks, Johanne
MacFarlane, Hannah (ORCID Profile 0000-0002-6724-4312)
Holmes, Nikki
Silva, Edward



Version: Published Version

License: Creative Commons Attribution

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