Angiogenic properties of placenta-derived extracellular vesicles in normal pregnancy and in preeclampsia


Angiogenesis is one of the main processes that coordinate the biological events leading to a successful pregnancy, and its imbalance characterizes several pregnancy-related diseases, including preeclampsia. Intracellular interactions via extracellular vesicles (EVs) contribute to pregnancy’s physiology and pathophysiology, and to the fetal–maternal interaction. The present review outlines the implications of EV-mediated crosstalk in the angiogenic process in healthy pregnancy and its dysregulation in preeclampsia. In particular, the effect of EVs derived from gestational tissues in pro and anti-angiogenic processes in the physiological and pathological setting is described. Moreover, the application of EVs from placental stem cells in the clinical setting is reported.

Publication DOI:
Divisions: College of Health & Life Sciences > School of Biosciences
College of Health & Life Sciences > Aston Medical School
College of Health & Life Sciences > Aston Medical School > Translational Medicine Research Group (TMRG)
Additional Information: Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( Funding: European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement number 765274.
Uncontrolled Keywords: Angiogenesis,Extracellular vesicles,Preeclampsia,Catalysis,Molecular Biology,Spectroscopy,Computer Science Applications,Physical and Theoretical Chemistry,Organic Chemistry,Inorganic Chemistry
Publication ISSN: 1422-0067
Last Modified: 14 May 2024 07:24
Date Deposited: 02 Jun 2021 14:41
Full Text Link:
Related URLs: https://www.mdp ... 0067/22/10/5402 (Publisher URL)
http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Review article
Published Date: 2021-05-20
Accepted Date: 2021-05-17
Authors: Gebara, Natalia
Correia, Yolanda
Wang, Keqing (ORCID Profile 0000-0001-6239-6344)
Bussolati, Benedetta



Version: Published Version

License: Creative Commons Attribution

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