Gebara, Natalia, Correia, Yolanda, Wang, Keqing and Bussolati, Benedetta (2021). Angiogenic properties of placenta-derived extracellular vesicles in normal pregnancy and in preeclampsia. International Journal of Molecular Sciences, 22 (10),
Abstract
Angiogenesis is one of the main processes that coordinate the biological events leading to a successful pregnancy, and its imbalance characterizes several pregnancy-related diseases, including preeclampsia. Intracellular interactions via extracellular vesicles (EVs) contribute to pregnancy’s physiology and pathophysiology, and to the fetal–maternal interaction. The present review outlines the implications of EV-mediated crosstalk in the angiogenic process in healthy pregnancy and its dysregulation in preeclampsia. In particular, the effect of EVs derived from gestational tissues in pro and anti-angiogenic processes in the physiological and pathological setting is described. Moreover, the application of EVs from placental stem cells in the clinical setting is reported.
Publication DOI: | https://doi.org/10.3390/ijms22105402 |
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Divisions: | College of Health & Life Sciences > School of Biosciences College of Health & Life Sciences > Aston Medical School College of Health & Life Sciences > Aston Medical School > Translational Medicine Research Group (TMRG) |
Additional Information: | Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Funding: European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement number 765274. |
Uncontrolled Keywords: | Angiogenesis,Extracellular vesicles,Preeclampsia,Catalysis,Molecular Biology,Spectroscopy,Computer Science Applications,Physical and Theoretical Chemistry,Organic Chemistry,Inorganic Chemistry |
Publication ISSN: | 1422-0067 |
Last Modified: | 04 Oct 2024 07:30 |
Date Deposited: | 02 Jun 2021 14:41 |
Full Text Link: | |
Related URLs: |
https://www.mdp ... 0067/22/10/5402
(Publisher URL) http://www.scop ... tnerID=8YFLogxK (Scopus URL) |
PURE Output Type: | Review article |
Published Date: | 2021-05-20 |
Accepted Date: | 2021-05-17 |
Authors: |
Gebara, Natalia
Correia, Yolanda Wang, Keqing ( 0000-0001-6239-6344) Bussolati, Benedetta |