Kainate and AMPA receptors in epilepsy:Cell biology, signalling pathways and possible crosstalk

Abstract

Epilepsy is caused when rhythmic neuronal network activity escapes normal control mechanisms, resulting in seizures. There is an extensive and growing body of evidence that the onset and maintenance of epilepsy involves alterations in the trafficking, synaptic surface expression and signalling of kainate and AMPA receptors (KARs and AMPARs). The KAR subunit GluK2 and AMPAR subunit GluA2 are key determinants of the properties of their respective assembled receptors. Both subunits are subject to extensive protein interactions, RNA editing and post-translational modifications. In this review we focus on the cell biology of GluK2-containing KARs and GluA2-containing AMPARs and outline how their regulation and dysregulation is implicated in, and affected by, seizure activity. Further, we discuss role of KARs in regulating AMPAR surface expression and plasticity, and the relevance of this to epilepsy. This article is part of the special issue on 'Glutamate Receptors - Kainate receptors'.

Publication DOI: https://doi.org/10.1016/j.neuropharm.2021.108569
Divisions: College of Health & Life Sciences > Aston Pharmacy School
College of Health & Life Sciences
College of Health & Life Sciences > Clinical and Systems Neuroscience
Additional Information: © 2021, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ Funding: We are grateful to the BBSRC (BB/R00787X/1), Wellcome Trust (220799/Z/20/Z) and Leverhulme Trust (RPG-2019-191) for financial support.
Uncontrolled Keywords: AMPA receptor,Synaptic Plasticity,epilepsy,glutamate receptors,kainate receptor,receptor trafficking,Glutamate receptors,Epilepsy,Synaptic plasticity,Receptor trafficking,Kainate receptor,Cellular and Molecular Neuroscience,Pharmacology
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Related URLs: https://www.sci ... 1234?via%3Dihub (Publisher URL)
http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Review article
Published Date: 2021-09-01
Published Online Date: 2021-04-26
Accepted Date: 2021-04-09
Submitted Date: 2021-01-14
Authors: Henley, Jeremy M
Nair, Jithin D
Seager, Richard
Yucel, Busra P
Woodhall, Gavin (ORCID Profile 0000-0003-1281-9008)
Henley, Benjamin S
Talandyte, Karolina
Needs, Hope I
Wilkinson, Kevin A

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Version: Accepted Version

Access Restriction: Restricted to Repository staff only until 26 April 2022.


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