Salman, Mootaz M., Al-Obaidi, Zaid, Kitchen, Philip, Loreto, Andrea, Bill, Roslyn M. and Wade-Martins, Richard (2021). Advances in Applying Computer-Aided Drug Design for Neurodegenerative Diseases. International Journal of Molecular Sciences, 22 (9),
Abstract
Neurodegenerative diseases (NDs) including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and Huntington’s disease are incurable and affect millions of people worldwide. The development of treatments for this unmet clinical need is a major global research challenge. Computer-aided drug design (CADD) methods minimize the huge number of ligands that could be screened in biological assays, reducing the cost, time, and effort required to develop new drugs. In this review, we provide an introduction to CADD and examine the progress in applying CADD and other molecular docking studies to NDs. We provide an updated overview of potential therapeutic targets for various NDs and discuss some of the advantages and disadvantages of these tools.
Publication DOI: | https://doi.org/10.3390/ijms22094688 |
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Divisions: | College of Health & Life Sciences College of Health & Life Sciences > School of Biosciences College of Health & Life Sciences > School of Biosciences > Cellular and Molecular Biomedicine Aston University (General) |
Additional Information: | © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
Uncontrolled Keywords: | Alzheimer’s disease,Amyotrophic lateral sclerosis,Brain diseases,CADD,CNS disorders,Dementia,Drug discovery,Huntington’s disease,Neurodegeneration,Parkinson’s disease,Catalysis,Molecular Biology,Spectroscopy,Computer Science Applications,Physical and Theoretical Chemistry,Organic Chemistry,Inorganic Chemistry |
Publication ISSN: | 1422-0067 |
Last Modified: | 29 Nov 2024 08:19 |
Date Deposited: | 30 Apr 2021 10:42 |
Full Text Link: | |
Related URLs: |
https://www.mdp ... -0067/22/9/4688
(Publisher URL) http://www.scop ... tnerID=8YFLogxK (Scopus URL) |
PURE Output Type: | Review article |
Published Date: | 2021-04-28 |
Accepted Date: | 2021-04-26 |
Authors: |
Salman, Mootaz M.
Al-Obaidi, Zaid Kitchen, Philip ( 0000-0002-1558-4673) Loreto, Andrea Bill, Roslyn M. ( 0000-0003-1331-0852) Wade-Martins, Richard |