Fish Oil Diet during Pre-mating, Gestation, and Lactation in Adult Offspring Rats on Cancer Cachexia Prevention


Scope: Nutritional supplementation of the maternal diet can modify the cancer susceptibility in adult offspring. Therefore, the authors evaluate the effects of a fish-oil diet administered to a long-term, during pre-mating, gestation, and lactation, in reducing cancer-cachexia damages in adult Walker-256 tumor-bearing offspring. Methods and Results: Female rats receive control or fish oil diet during pre-mating, gestation, and lactation. After weaning, male offspring are fed the control diet until adulthood and distributed in (C) control adult-offspring; (W) adult tumor-bearing offspring; (OC) adult-offspring of maternal fish oil diet; (WOC) adult tumor-bearing offspring of maternal fish oil diet groups. Fat body mass is preserved, muscle expression of mechanistic target of rapamicin (mTOR) and eukariotic binding protein of eukariotic factor 4E (4E-BP1) is modified, being associated with lower 20S proteasome protein expression, and the liver alanine aminotransferase (ALT) enzyme content maintained in the WOC group. Also, the OC group shows reduced triglyceridemia. Conclusion: In this experimental model of cachexia, the long-term maternal supplementation is a positive strategy to improve liver function and lipid metabolism, as well as to modify muscle proteins expression in the mTOR pathway and also reduce the 20S muscle proteasome protein, without altering the tumor development and muscle wasting in adult tumor-bearing offspring.

Publication DOI:
Divisions: College of Health & Life Sciences > School of Biosciences
Funding Information: The authors thank Rogério Willians dos Santos for assistance with animal care, and Designer A.C. Gomes Marcondes for the graphical art. Bioclin‐Quibasa, Brazil, kindly donated serum analyses kits, and L‐cistine was donated by Ajinomoto Brazil (Sao Paulo,
Additional Information: This is the peer reviewed version of the following article: de Oliveira, S.C.P., Miyaguti, N.A.d.S., Russell, S.T., Tobar, N., Geraldo, M.V. and Gomes‐Marcondes, M.C.C. (2021), Fish Oil Diet during Pre‐mating, Gestation, and Lactation in Adult Offspring Rats on Cancer Cachexia Prevention. Mol. Nutr. Food Res.. Accepted Author Manuscript 2000863, which has been published in final form at  This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.
Uncontrolled Keywords: cachexia,fish oil,maternal influence,nutritional supplementation,omega-3,Biotechnology,Food Science
Publication ISSN: 1613-4133
Last Modified: 07 May 2024 07:14
Date Deposited: 03 Mar 2021 15:03
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Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2021-05
Published Online Date: 2021-03-02
Accepted Date: 2021-02-18
Authors: de Oliveira, Sarah Christine Pereira
Miyaguti, Natália Angelo da Silva
Russell, Steven Thomas (ORCID Profile 0000-0002-5491-900X)
Tobar, Natália
Geraldo, Murilo Vieira
Gomes-Marcondes, Maria Cristina Cintra



Version: Accepted Version

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