Skin complications of diabetes mellitus revealed by polarized hyperspectral imaging and machine learning


Aging and diabetes lead to protein glycation and cause dysfunction of collagen-containing tissues. The accompanying structural and functional changes of collagen significantly contribute to the development of various pathological malformations affecting the skin, blood vessels, and nerves, causing a number of complications, increasing disability risks and threat to life. In fact, no methods of non-invasive assessment of glycation and associated metabolic processes in biotissues or prediction of possible skin complications, e.g., ulcers, currently exist for endocrinologists and clinical diagnosis. In this publication, utilizing emerging photonics-based technology, innovative solutions in machine learning, and definitive physiological characteristics, we introduce a diagnostic approach capable of evaluating the skin complications of diabetes mellitus at the very earlier stage. The results of the feasibility studies, as well as the actual tests on patients with diabetes and healthy volunteers, clearly show the ability of the approach to differentiate diabetic and control groups. Furthermore, the developed in-house polarization-based hyperspectral imaging technique accomplished with the implementation of the artificial neural network provides new horizons in the study and diagnosis of age-related diseases.

Publication DOI:
Divisions: College of Engineering & Physical Sciences > Aston Institute of Photonics Technology (AIPT)
College of Engineering & Physical Sciences
College of Engineering & Physical Sciences > School of Engineering and Technology > Mechanical, Biomedical & Design
Additional Information: This work is licensed under a Creative Commons Attribution 4.0 License. For more information, see Funding: Viktor Dremin kindly acknowledges personal support from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 839888. The authors acknowledge the support of the Academy of Finland (grants: 314369 – RADDESS programme, 290596, and 318281) as well as INFOTECH strategic funding. (
Uncontrolled Keywords: Hyperspectral imaging,diabetes mellitus,polarization,skin complications,Software,Radiological and Ultrasound Technology,Computer Science Applications,Electrical and Electronic Engineering
Publication ISSN: 1558-254X
Last Modified: 14 May 2024 07:20
Date Deposited: 14 Jan 2021 08:32
Full Text Link:
Related URLs: https://ieeexpl ... ocument/9316275 (Publisher URL)
http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2021-04
Published Online Date: 2021-01-06
Accepted Date: 2021-01-01
Authors: Dremin, Viktor (ORCID Profile 0000-0001-6974-3505)
Marcinkevics, Zbignevs
Zherebtsov, Evgeny
Popov, Alexey
Grabovskis, Andris
Kronberga, Hedviga
Geldnere, Kristine
Doronin, Alexander
Meglinski, Igor (ORCID Profile 0000-0002-7613-8191)
Bykov, Alexander



Version: Accepted Version

License: Creative Commons Attribution

| Preview

Export / Share Citation


Additional statistics for this record