Application of optical non-invasive methods to diagnose the state of the lower limb tissues in patients with diabetes mellitus

Abstract

The paper shows the possibility of assessing the functional state of microcirculatory-tissue systems of patients with diabetes mellitus by laser Doppler flowmetry (LDF), diffuse reflectance spectroscopy (DRS) and fluorescence spectroscopy (FS) methods. A review of the existing non-invasive optical technologies used to assess the state of microcirculation and oxygen metabolism in tissues of patients with diabetes is conducted. A series of experimental studies involving 76 patients with diabetes and 46 healthy volunteers was carried out. A wavelet analysis of LDF-grams was used to evaluate the adaptive changes of microcirculation during the temperature tests. The obtained data revealed that the proposed methodology in the form of combined use of several diagnostic technologies (LDF, FS and DRS) allows us to detect the presence or absence of trophic disorders and to evaluate adaptation processes during thermal tests.

Publication DOI: https://doi.org/10.1088/1742-6596/929/1/012069
Divisions: College of Engineering & Physical Sciences > Aston Institute of Photonics Technology (AIPT)
College of Engineering & Physical Sciences
Funding Information: This work was supported by grant of the President of the Russian Federation for state support of young Russian scientists + MK-7168.2016.8.
Additional Information: Content from this work may be used under the terms of theCreative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI Funding Information: This work was supported by grant of the President of the Russian Federation for state support of young Russian scientists + MK-7168.2016.8.
Uncontrolled Keywords: Physics and Astronomy(all)
Publication ISSN: 1742-6596
Last Modified: 20 May 2024 07:36
Date Deposited: 21 Dec 2020 12:30
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Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Conference article
Published Date: 2017-11-27
Accepted Date: 2016-11-01
Authors: Zharkikh, E. V.
Dremin, V. V. (ORCID Profile 0000-0001-6974-3505)
Filina, M. A.
Makovik, I. N.
Potapova, E. V.
Zherebtsov, E. A. (ORCID Profile 0000-0002-3635-1430)
Zherebtsova, A. I.
Dunaev, A. V.

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