Potapova, Elena, Kandurova, Ksenia, Shupletsov, Valery, Seryogina, Evgeniya, Dremin, Viktor, Zherebtsov, Evgeny, Alekseyev, Alexander, Mamoshin, Andrian, Ivanov, Yuri, Panchenkov, Dmitry and Dunaev, Andrey (2020). Optical fine needle biopsy in hepatocellular carcinoma mouse model. Proceedings of SPIE - The International Society for Optical Engineering, 11363 ,
Abstract
The paper describes the results of experimental studies using custom developed optical biopsy system for diagnostics in vivo during the procedure of fine needle aspiration biopsy. Experimental studies were conducted in laboratory mice with inoculated hepatocellular carcinoma. The measurements were carried out using fluorescence spectroscopy and diffuse reflectance spectroscopy methods to reveal metabolic and morphological changes in tissues. The results show that the developed approach is sensitive for cancer detection. Quantified differences in the maximum of fluorescence spectra and diffuse reflectance spectra between tumor and normal tissues were demonstrated and approved with morphological analysis.
| Publication DOI: | https://doi.org/10.1117/12.2555154 |
|---|---|
| Divisions: | College of Engineering & Physical Sciences > Aston Institute of Photonics Technology (AIPT) |
| Funding Information: | This study was supported by the Russian Science Foundation under project № 18-15-00201. Authors are very grateful to Dr. Olga V. Morozova (N.N. Blokhin Russian Cancer Research Center, Moscow, Russia) for tumor cell inoculation. |
| Additional Information: | Copyright 2020 SPIE. One print or electronic copy may be made for personal use only. Systematic reproduction, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited. |
| Uncontrolled Keywords: | Diffuse reflectance spectroscopy,Fine needle aspiration biopsy,Fluorescence spectroscopy,Hepatocellular carcinoma,Liver cancer,Optical biopsy,Electronic, Optical and Magnetic Materials,Condensed Matter Physics,Computer Science Applications,Applied Mathematics,Electrical and Electronic Engineering |
| Publication ISSN: | 1996-756X |
| Last Modified: | 01 Nov 2024 08:27 |
| Date Deposited: | 18 Dec 2020 13:25 |
| Full Text Link: | |
| Related URLs: |
http://www.scop ... tnerID=8YFLogxK
(Scopus URL) https://www.spi ... 5154.full?SSO=1 (Publisher URL) |
PURE Output Type: | Conference article |
| Published Date: | 2020-04-02 |
| Accepted Date: | 2020-04-01 |
| Authors: |
Potapova, Elena
Kandurova, Ksenia Shupletsov, Valery Seryogina, Evgeniya Dremin, Viktor ( 
0000-0001-6974-3505)
Zherebtsov, Evgeny Alekseyev, Alexander Mamoshin, Andrian Ivanov, Yuri Panchenkov, Dmitry Dunaev, Andrey |
CORE (COnnecting REpositories)
CORE (COnnecting REpositories)