Brain metabolism changes in cases of impaired breathing or blood circulation in rodents evaluated by real time optical spectroscopy methods


The aim of the study was to compare the metabolic activity of brain cortex after the acute hypoxia caused by the impairment of breathing or blood circulation. Male Wistar rats were randomized in two groups: impaired breathing and blood circulation failure groups. Fluorescence under 365 and 450 nm excitation and diffuse reflectance intensity at 550-820 nm range were estimated. We found that after long-term hypoxic conditions, notable metabolic changes occur. We suppose that oxygen deficiency causes an activation of the GABA shunt mechanism. In cases of blood circulation failure, fluorescence intensity changes faster than in cases of breathing impairment.

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Divisions: College of Engineering & Physical Sciences > Aston Institute of Photonics Technology (AIPT)
College of Engineering & Physical Sciences > School of Engineering and Technology > Mechanical, Biomedical & Design
Additional Information: Copyright 2020 SPIE. One print or electronic copy may be made for personal use only. Systematic reproduction, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited. Copyright 2020 Elsevier B.V., All rights reserved.
Uncontrolled Keywords: Brain metabolism,Diffuse reflectance spectra,FAD,Fluorescence spectroscopy,Laser speckle contrast imaging,NADH,Neuronal hypoxia,Resuscitation procedures,Electronic, Optical and Magnetic Materials,Biomaterials,Atomic and Molecular Physics, and Optics,Radiology Nuclear Medicine and imaging
Publication ISSN: 1605-7422
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Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
https://www.spi ... 2.2545708.short (Publisher URL)
PURE Output Type: Conference article
Published Date: 2020-02-21
Authors: Piavchenko, Gennadii A.
Seryogina, Evgeniya S.
Kandurova, Ksenia Yu
Shupletsov, Valery V.
Kozlov, Igor O.
Stavtsev, Dmitry D.
Stelmashchuk, Olga A.
Zherebtsov, Evgeny A.
Dremin, Viktor V. (ORCID Profile 0000-0001-6974-3505)
Alekseyev, Aleksander G.
Kuznetsov, Sergey L.
Dunaev, Andrey V.
Meglinski, Igor V. (ORCID Profile 0000-0002-7613-8191)



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