The global burden of illness of peanut allergy:A comprehensive literature review


Peanut allergy (PA) currently affects approximately 2% of the general population of Western nations and may be increasing in prevalence. Patients with PA and their families/caregivers bear a considerable burden of self-management to avoid accidental peanut exposure and to administer emergency medication (adrenaline) if needed. Compared with other food allergies, PA is associated with higher rates of accidental exposure, severe reactions and potentially fatal anaphylaxis. Approximately 7%-14% of patients with PA experience accidental peanut exposure annually, and one-third to one-half may experience anaphylaxis, although fatalities are rare. These risks impose considerably high healthcare utilization and economic costs for patients with PA and restrictions on daily activities. Measures to accommodate patients with PA are often inadequate, with inconsistent standards for food labelling and inadequate safety policies in public establishments such as restaurants and schools. Children with PA are often bullied, resulting in sadness, humiliation and anxiety. These factors cumulatively contribute to significantly reduced health-related quality of life for patients with PA and families/caregivers. Such factors also provide essential context for risk/benefit assessments of new PA therapies. This narrative review comprehensively assessed the various factors comprising the burden of PA.

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Divisions: College of Health & Life Sciences > School of Psychology
College of Health & Life Sciences
Additional Information: © 2020 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Uncontrolled Keywords: accidental exposure,anaphylaxis,burden,health-related quality of life,peanut allergy,Immunology and Allergy,Immunology
Publication ISSN: 1398-9995
Last Modified: 16 Jul 2024 07:19
Date Deposited: 23 Nov 2020 08:49
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Related URLs: https://onlinel ... .1111/all.14666 (Publisher URL)
http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Review article
Published Date: 2021-05
Published Online Date: 2020-11-20
Accepted Date: 2020-11-01
Authors: Lieberman, Jay A
Gupta, Ruchi S
Knibb, Rebecca C (ORCID Profile 0000-0001-5561-0904)
Haselkorn, Tmirah
Tilles, Stephen
Mack, Douglas P
Pouessel, Guillaume



Version: Accepted Version

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Version: Published Version

License: Creative Commons Attribution Non-commercial No Derivatives

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