Optimized Implementation of cardiac resynchronization therapy:a call for action for referral and optimization of care


Cardiac resynchronization therapy (CRT) is one of the most effective therapies for heart failure with reduced ejection fraction and leads to improved quality of life, reductions in heart failure hospitalization rates and reduces all‐cause mortality. Nevertheless, up to two‐thirds of eligible patients are not referred for CRT. Furthermore, post implantation follow‐up is often fragmented and suboptimal, hampering the potential maximal treatment effect. This joint position statement from three ESC Associations, HFA, EHRA and EACVI focuses on optimized implementation of CRT. We offer theoretical and practical strategies to achieve more comprehensive CRT referral and post‐procedural care by focusing on four actionable domains; (I) overcoming CRT under‐utilization, (II) better understanding of pre‐implant characteristics, (III) abandoning the term ‘non‐response’ and replacing this by the concept of disease modification, and (IV) implementing a dedicated post‐implant CRT care pathway.

Publication DOI: https://doi.org/10.1002/ejhf.2046
Divisions: College of Health & Life Sciences > Aston Medical School > Translational Medicine Research Group (TMRG)
College of Health & Life Sciences > Aston Medical School
Additional Information: This is the peer reviewed version of the following article: Mullens, W., Auricchio, A., Martens, P., Witte, K., Cowie, M.R., Delgado, V., Dickstein, K., Linde, C., Vernooy, K., Leyva, F., Bauersachs, J., Israel, C.W., Lund, L., Donal, E., Boriani, G., Jaarsma, T., Berruezo, A., Traykov, V., Yousef, Z., Kalarus, Z., Nielsen, J.C., Steffel, J., Vardas, P., Coats, A., Seferovic, P., Edvardsen, T., Heidbuchel, H., Ruschitzka, F. and Leclercq, C. (2020), Optimized Implementation of cardiac resynchronization therapy – a call for action for referral and optimization of care. Eur J Heart Fail. Accepted Author Manuscript., which has been published in final form at https://doi.org/10.1002/ejhf.2046.  This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.
Uncontrolled Keywords: Cardiology and Cardiovascular Medicine
Publication ISSN: 1879-0844
Full Text Link:
Related URLs: https://onlinel ... .1002/ejhf.2046 (Publisher URL)
PURE Output Type: Article
Published Date: 2020-12
Published Online Date: 2020-11-02
Accepted Date: 2020-10-29
Authors: Mullens, Wilfried
Auricchio, Angelo
Martens, Pieter
Witte, Klaus
Cowie, Martin R
Delgado, Victoria
Dickstein, Kenneth
Linde, Cecilia
Vernooy, Kevin
Leyva, Francisco
Bauersachs, Johann
Israel, Carsten W
Lund, Lars
Donal, Erwan
Boriani, Giuseppe
Jaarsma, Tiny
Berruezo, Antonio
Traykov, Vassil
Yousef, Zaheer
Kalarus, Zbigniew
Nielsen, Jens Cosedis
Steffel, Jan
Vardas, Panos
Coats, Andrew
Seferovic, Petar
Edvardsen, Thor
Heidbuchel, Hein
Ruschitzka, Frank
Leclercq, Christophe



Version: Accepted Version

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