3D Mueller-matrix-based azimuthal invariant tomography of polycrystalline structure within benign and malignant soft-tissue tumours

Abstract

We introduce a method of azimuthally invariant 3D Mueller-matrix (MM) layer-by-layer mapping of the phase and amplitude parameters of anisotropy of the partially depolarizing layers of benign (adenoma) and malignant (carcinoma) prostate tumours. The technique is based on the analysis of spatial variations of Mueller matrix invariant (MMI) of histological sections of benign (adenoma) and malignant (carcinoma) tissue samples. The phase dependence of magnitudes of the first-to-fourth order statistical moments is applied to characterize 3D spatial distributions of MMI of linear and circular birefringence and dichroism of prostate tumours. The high order statistical moments and phase sections of the optimal differentiation of the polycrystalline structure of tissue samples are revealed. The obtained results are compared with the results obtained by conventional methods utilizing polarized light, including 2D and 3D Mueller matrix imaging.

Publication DOI: https://doi.org/10.1088/1612-202x/abbee0
Divisions: College of Engineering & Physical Sciences > School of Engineering and Technology > Mechanical, Biomedical & Design
Additional Information: Original content from this work may be used under the terms of the Creative Commons Attribution 3.0 license. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI. Funding: This project has received funding from the ATTRACT project funded by the EC under Grant Agreement 777222, Academy of Finland (Grant No. 325097), and INFOTECH strategic funding and National Research Foundation of Ukraine Fund Program. IM also acknowledges partial support from MEPhI Academic Excellence Project (Contract No. 02.a03.21.0005), Russian Science Foundation (Project 19-72- 30012), the National Research Tomsk State University Academic D.I. Mendeleev Fund Program
Uncontrolled Keywords: Azimuthal invariant,Mueller matrix,Optical anisotropy,Polarized light,Polycrystalline structure,Soft-tissue tumours,Instrumentation,Physics and Astronomy (miscellaneous)
Publication ISSN: 1612-202X
Full Text Link:
Related URLs: https://iopscie ... 612-202X/abbee0 (Publisher URL)
http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2020-11
Published Online Date: 2020-10-23
Accepted Date: 2020-09-19
Authors: Peyvasteh, Motahareh
Tryfonyuk, Liliya
Ushenko, Vladimir
Syvokorovskaya, Anastasia-Vira
Dubolazov, Alexander
Vanchulyak, Oleg
Ushenko, Alexander
Ushenko, Yuri
Gorsky, Mykhailo
Sidor, Maxim
Tomka, Yuriy
Soltys, Iryna
Bykov, Alexander
Meglinski, Igor (ORCID Profile 0000-0002-7613-8191)

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