Rationale and design of the randomized multicentre His Optimized Pacing Evaluated for Heart Failure (HOPE-HF) trial:HOPE HF Trial rationale and design


Aims In patients with heart failure and a pathologically prolonged PR interval, left ventricular (LV) filling can be improved by shortening atrioventricular delay using His‐bundle pacing. His‐bundle pacing delivers physiological ventricular activation and has been shown to improve acute haemodynamic function in this group of patients. In the HOPE‐HF (His Optimized Pacing Evaluated for Heart Failure) trial, we are investigating whether these acute haemodynamic improvements translate into improvements in exercise capacity and heart failure symptoms. Methods and results This multicentre, double‐blind, randomized, crossover study aims to randomize 160 patients with PR prolongation (≥200 ms), LV impairment (EF ≤ 40%), and either narrow QRS (≤140 ms) or right bundle branch block. All patients receive a cardiac device with leads positioned in the right atrium and the His bundle. Eligible patients also receive a defibrillator lead. Those not eligible for implantable cardioverter defibrillator have a backup pacing lead positioned in an LV branch of the coronary sinus. Patients are allocated in random order to 6 months of (i) haemodynamically optimized dual chamber His‐bundle pacing and (ii) backup pacing only, using the non‐His ventricular lead. The primary endpoint is change in exercise capacity assessed by peak oxygen uptake. Secondary endpoints include change in ejection fraction, quality of life scores, B‐type natriuretic peptide, daily patient activity levels, and safety and feasibility assessments of His‐bundle pacing. Conclusions Hope‐HF aims to determine whether correcting PR prolongation in patients with heart failure and narrow QRS or right bundle branch block using haemodynamically optimized dual chamber His‐bundle pacing improves exercise capacity and symptoms. We aim to complete recruitment by the end of 2018 and report in 2020.

Publication DOI: https://doi.org/10.1002/ehf2.12315
Divisions: College of Health & Life Sciences > Aston Medical School > Translational Medicine Research Group (TMRG)
College of Health & Life Sciences > Aston Medical School
Additional Information: © 2018 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of the European Society of Cardiology. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Publication ISSN: 2055-5822
Full Text Link:
Related URLs: http://doi.wile ... 1002/ehf2.12315 (Publisher URL)
PURE Output Type: Article
Published Date: 2018-10-01
Published Online Date: 2018-07-09
Accepted Date: 2018-05-30
Authors: Keene, Daniel
Arnold, Ahran
Shun-shin, Matthew J.
Howard, James P.
Sohaib, Sm Afzal
Moore, Philip
Tanner, Mark
Quereshi, Norman
Muthumala, Amal
Chandresekeran, Badrinathan
Foley, Paul
Leyva, Francisco
Adhya, Shaumik
Falaschetti, Emanuela
Tsang, Hilda
Vijayaraman, Pugal
Cleland, John G.f.
Stegemann, Berthold (ORCID Profile 0000-0003-2841-8022)
Francis, Darrel P.
Whinnett, Zachary I.



Version: Published Version

License: Creative Commons Attribution

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