Jackson, Tom, Lenarczyk, Radoslaw, Sterlinski, Maciej, Sokal, Adam, Francis, Darrell, Whinnett, Zachary, Van Heuverswyn, Frederic, Vanderheyden, Marc, Heynens, Joeri, Stegemann, Berthold, Cornelussen, Richard and Rinaldi, Christopher Aldo (2018). Left ventricular scar and the acute hemodynamic effects of multivein and multipolar pacing in cardiac resynchronization. IJC Heart & Vasculature, 19 , pp. 14-19.
Abstract
Background We sought to determine whether presence, amount and distribution of scar impacts the degree of acute hemodynamic response (AHR) with multisite pacing. Multi-vein pacing (MVP) or multipolar pacing (MPP) with a multi-electrode left ventricular (LV) lead may offer benefits over conventional biventricular pacing in patients with myocardial scar. Methods In this multi-center study left bundle branch block patients underwent an hemodynamic pacing study measuring LV dP/dtmax. Patients had cardiac magnetic resonance scar imaging to assess the effect of scar presence, amount and distribution on AHR. Results 24 patients (QRS 171 ± 20 ms) completed the study (83% male). An ischemic etiology was present in 58% and the mean scar volume was 6.0 ± 7.0%. Overall discounting scar, MPP and MVP showed no significant AHR increase compared to an optimized “best BiV” (BestBiV) site. In a minority of patients (6/24) receiver-operator characteristic analysis of scar volume (cut off 8.48%) predicted a small AHR improvement with MPP (sensitivity 83%, specificity 94%) but not MVP. Patients with scar volume > 8.48% had a MPP-BestBiV of 3 ± 6.3% vs. −6.4 ± 7.7% for those below the cutoff. There was a significant correlation between the difference in AHR and scar volume for MPP-BestBiV (R = 0.49, p = 0.02) but not MVP-BestBiV(R = 0.111, p = 0.62). The multielectrode lead positioned in scar predicted MPP AHR improvement (p = 0.04). Conclusions Multisite pacing with MPP and MVP shows no AHR benefit in all-comers compared to optimized BestBiV pacing. There was a minority of patients with significant scar volume in relation to the LV site that exhibited a small AHR improvement with MPP.
Publication DOI: | https://doi.org/10.1016/j.ijcha.2018.03.006 |
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Divisions: | College of Health & Life Sciences > Aston Medical School |
Additional Information: | © 2018 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/) |
Publication ISSN: | 2352-9067 |
Last Modified: | 30 Sep 2024 12:34 |
Date Deposited: | 27 Oct 2020 13:35 |
Full Text Link: | |
Related URLs: |
https://linking ... 352906718300265
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PURE Output Type: | Article |
Published Date: | 2018-06-01 |
Published Online Date: | 2018-04-10 |
Accepted Date: | 2018-03-21 |
Authors: |
Jackson, Tom
Lenarczyk, Radoslaw Sterlinski, Maciej Sokal, Adam Francis, Darrell Whinnett, Zachary Van Heuverswyn, Frederic Vanderheyden, Marc Heynens, Joeri Stegemann, Berthold ( 0000-0003-2841-8022) Cornelussen, Richard Rinaldi, Christopher Aldo |
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