Integration of paper microfluidic sensors into contact lenses for tear fluid analysis


In this article, using the integration of paper microfluidics within laser-inscribed commercial contact lenses, we demonstrate the multiplexed detection of clinically relevant analytes including hydrogen ions, proteins, glucose, nitrites and l-ascorbic acid, all sampled directly from model tears. In vitro measurements involved the optimization of colorimetric assays, with readouts collected, stored and analyzed using a bespoke Tears Diagnostics smartphone application prototype. We demonstrate the potential of the device to perform discrete measurements either for medical diagnosis or disease screening in the clinic or at the point-of-care (PoC), with future applications including monitoring of ocular infections, uveitis, diabetes, keratopathies and assessing oxidative stress.

Publication DOI:
Divisions: College of Health & Life Sciences > School of Optometry > Optometry
Additional Information: Funding Information: R. M. acknowledges the University of Birmingham, Birmingham, UK for PhD funding. A. K. Y. thanks the Engineering and Physical Sciences Research Council (EPSRC) for a New Investigator Award (EP/T013567/1).
Uncontrolled Keywords: Bioengineering,Biochemistry,General Chemistry,Biomedical Engineering
Publication ISSN: 1473-0189
Last Modified: 16 Jul 2024 07:18
Date Deposited: 21 Sep 2020 09:16
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PURE Output Type: Article
Published Date: 2020-11-07
Published Online Date: 2020-09-04
Accepted Date: 2020-08-28
Authors: Moreddu, Rosalia
Elsherif, Mohamed
Adams, Hadie
Moschou, Despina
Cordeiro, Maria F.
Wolffsohn, James S. (ORCID Profile 0000-0003-4673-8927)
Vigolo, Daniele
Butt, Haider
Cooper, Jonathan M.
Yetisen, Ali K.



Version: Accepted Version

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