The Effect of Dietary Supplementation of Green Tea Catechins on Cardiovascular Disease Risk Markers in Humans: A Systematic Review of Clinical Trials


Green tea catechins (GTCs) are secondary plant metabolites that have been associated with health benefits in human trials. As such, they have the potential to reduce cardiovascular disease (CVD) risk; however, results are not consistent. This systematic review of the published data assessed the putative effect of GTCs supplementation on anthropometric, blood pressure, and biochemical measures associated with CVD risk. It was conducted in accordance with the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines exploring four major electronic databases (MEDLINE, Cochrane Library, Web of Science, and Scopus). Studies were included if they were published in peer-reviewed journals in English from 1990 until October 2015, and were human double-blind randomized and placebo-controlled trials (RCTs). From 122,428 articles initially identified, after two levels of screening, seven studies met the inclusion criteria. The review revealed consistent and significant (p ≤ 0.05) reductions in body mass index (BMI), blood pressure and plasma lipids; however, this effect would have been less if between-group effects had been considered. The current evidence base also has considerable methodological limitations due to suboptimal statistical methods used in data analyses. Future research efforts must aim to rectify this paucity of evidence with well-designed and well-reported prospective studies

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Divisions: College of Health & Life Sciences > Aston Medical School
Additional Information: © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (
Publication ISSN: 2306-5710
Last Modified: 14 May 2024 07:16
Date Deposited: 14 Sep 2020 12:40
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Related URLs: https://www.mdp ... 306-5710/2/2/16 (Publisher URL)
PURE Output Type: Literature review
Published Date: 2016-06-21
Accepted Date: 2016-06-10
Authors: Lau, Sarah
Georgousopoulou, Ekavi
Kellett, Jane
Thomas, Jackson
McKune, Andrew
Mellor, Duane (ORCID Profile 0000-0002-1369-3868)
Roach, Paul
Naumovski, Nenad



Version: Published Version

License: Creative Commons Attribution

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