Cholesterol and oxysterol sulfates:Pathophysiological roles and analytical challenges

Abstract

Cholesterol and oxysterol sulfates are important regulators of lipid metabolism, inflammation, cell apoptosis, and cell survival. Among the sulfate-based lipids, cholesterol sulfate (CS) is the most studied lipid both quantitatively and functionally. Despite the importance, very few studies have analysed and linked the actions of oxysterol sulfates to their physiological and pathophysiological roles. Overexpression of sulfotransferases confirmed the formation of a range of oxysterol sulfates and their antagonistic effects on liver X receptors (LXRs) prompting further investigations how are the changes to oxysterol/oxysterol sulfate homeostasis can contribute to LXR activity in the physiological milieu. Here, we aim to bring together for novel roles of oxysterol sulfates, the available techniques and the challenges associated with their analysis. Understanding the oxysterol/oxysterol sulfate levels and their pathophysiological mechanisms could lead to new therapeutic targets for metabolic diseases.

Publication DOI: https://doi.org/10.1111/bph.15227
Divisions: College of Health & Life Sciences > Aston Medical School > Translational Medicine Research Group (TMRG)
College of Health & Life Sciences > Aston Medical School
College of Health & Life Sciences > School of Biosciences
Uncontrolled Keywords: cholesterol sulfate,mass spectrometry,oxysterol sulfate,oxysterols,Pharmacology
Publication ISSN: 1476-5381
Last Modified: 28 May 2024 07:17
Date Deposited: 14 Aug 2020 10:25
Full Text Link:
Related URLs: https://bpspubs ... .1111/bph.15227 (Publisher URL)
http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Review article
Published Date: 2021-08
Published Online Date: 2020-08-06
Accepted Date: 2020-07-20
Authors: Diaz Sanchez, Lorena
Pontini, Lorenzo
Marinozzi, Maura
Sanchez Aranguren, Lissette (ORCID Profile 0000-0002-4663-5752)
Reis, Ana
Dias, Irundika (ORCID Profile 0000-0002-6620-8221)

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License: Creative Commons Attribution

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