A dissection of SARS‑CoV2 with clinical implications (Review)


We are being confronted with the most consequential pandemic since the Spanish flu of 1918‑1920 to the extent that never before have 4 billion people quarantined simultaneously; to address this global challenge we bring to the forefront the options for medical treatment and summarize SARS‑CoV2 structure and functions, immune responses and known treatments. Based on literature and our own experience we propose new interventions, including the use of amiodarone, simvastatin, pioglitazone and curcumin. In mild infections (sore throat, cough) we advocate prompt local treatment for the naso‑pharynx (inhalations; aerosols; nebulizers); for moderate to severe infections we propose a tried‑and‑true treatment: the combination of arginine and ascorbate, administered orally or intravenously. The material is organized in three sections: i) Clinical aspects of COVID‑19; acute respiratory distress syndrome (ARDS); known treatments; ii) Structure and functions of SARS‑CoV2 and proposed antiviral drugs; iii) The combination of arginine‑ascorbate.

Publication DOI: https://doi.org/10.3892/ijmm.2020.4636
Divisions: College of Health & Life Sciences > Aston Pharmacy School
College of Health & Life Sciences > Chronic and Communicable Conditions
College of Health & Life Sciences
College of Health & Life Sciences > School of Biosciences > Cellular and Molecular Biomedicine
Additional Information: © Stancioiu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Uncontrolled Keywords: Genetics
Publication ISSN: 1107-3756
Last Modified: 09 Apr 2024 07:14
Date Deposited: 23 Jun 2020 11:19
Full Text Link:
Related URLs: http://www.span ... /ijmm.2020.4636 (Publisher URL)
http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Review article
Published Date: 2020-08-01
Published Online Date: 2020-06-10
Accepted Date: 2020-06-09
Authors: Stancioiu, Felician
Papadakis, Georgios
Kteniadakis, Stelios
Izotov, Boris
Coleman, Michael (ORCID Profile 0000-0002-5510-6852)
Spandidos, Demetrios
Tsatsakis, Aristidis



Version: Published Version

License: Creative Commons Attribution

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