Stancioiu, Felician, Papadakis, Georgios, Kteniadakis, Stelios, Izotov, Boris, Coleman, Michael, Spandidos, Demetrios and Tsatsakis, Aristidis (2020). A dissection of SARS‑CoV2 with clinical implications (Review). International Journal of Molecular Medicine, 46 (2), pp. 489-508.
Abstract
We are being confronted with the most consequential pandemic since the Spanish flu of 1918‑1920 to the extent that never before have 4 billion people quarantined simultaneously; to address this global challenge we bring to the forefront the options for medical treatment and summarize SARS‑CoV2 structure and functions, immune responses and known treatments. Based on literature and our own experience we propose new interventions, including the use of amiodarone, simvastatin, pioglitazone and curcumin. In mild infections (sore throat, cough) we advocate prompt local treatment for the naso‑pharynx (inhalations; aerosols; nebulizers); for moderate to severe infections we propose a tried‑and‑true treatment: the combination of arginine and ascorbate, administered orally or intravenously. The material is organized in three sections: i) Clinical aspects of COVID‑19; acute respiratory distress syndrome (ARDS); known treatments; ii) Structure and functions of SARS‑CoV2 and proposed antiviral drugs; iii) The combination of arginine‑ascorbate.
Publication DOI: | https://doi.org/10.3892/ijmm.2020.4636 |
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Divisions: | College of Health & Life Sciences > Aston Pharmacy School College of Health & Life Sciences > Chronic and Communicable Conditions College of Health & Life Sciences College of Health & Life Sciences > School of Biosciences > Cellular and Molecular Biomedicine |
Additional Information: | © Stancioiu et al. This is an open access article distributed under the terms of Creative Commons Attribution License. |
Uncontrolled Keywords: | Genetics |
Publication ISSN: | 1107-3756 |
Last Modified: | 09 Oct 2024 07:23 |
Date Deposited: | 23 Jun 2020 11:19 |
Full Text Link: | |
Related URLs: |
http://www.span ... /ijmm.2020.4636
(Publisher URL) http://www.scop ... tnerID=8YFLogxK (Scopus URL) |
PURE Output Type: | Review article |
Published Date: | 2020-08-01 |
Published Online Date: | 2020-06-10 |
Accepted Date: | 2020-06-09 |
Authors: |
Stancioiu, Felician
Papadakis, Georgios Kteniadakis, Stelios Izotov, Boris Coleman, Michael ( 0000-0002-5510-6852) Spandidos, Demetrios Tsatsakis, Aristidis |