Agache, Ioana, Akdis, Cezmi, Akdis, Mubeccel, Canonica, Giorgio Walter, Casale, Thomas, Chivato, Tomas, Corren, Jonathan, Chu, Derek K., Del Giacco, Stefano, Eiwegger, Thomas, Flood, Breda, Firinu, Davide, Gern, James E., Hamelmann, Eckard, Hanania, Nicola, Hernández‐martín, Irene, Knibb, Rebeca, Mäkelä, Mika, Nair, Parameswaran, O13037mahony, Liam, Papadopoulos, Nikolaos G., Papi, Alberto, Park, Hae‐sim, Pérez De Llano, Luis, Pfaar, Oliver, Quirce, Santiago, Sastre, Joaquin, Shamji, Mohamed, Schwarze, Jurgen, Palomares, Oscar and Jutel, Marek (2021). EAACI Biologicals Guidelines – Recommendations for severe asthma. Allergy, 76 (1), pp. 14-44.
Abstract
Severe asthma imposes a significant burden on patients, families and healthcare systems. Management is difficult, due to disease heterogeneity, comorbidities, complexity in care pathways and differences between national or regional healthcare systems. Better understanding of the mechanisms has enabled a stratified approach to the management of severe asthma, supporting the use of targeted treatments with biologicals. However, there are still many issues that require further clarification. These include selection of a certain biological (as they all target overlapping disease phenotypes), the definition of response, strategies to enhance the responder rate, the duration of treatment and its regimen (in the clinic or home‐based) and its cost‐effectiveness. The EAACI Guidelines on the use of biologicals in severe asthma follow the GRADE approach in formulating recommendations for each biological and each outcome. In addition, a management algorithm for the use of biologicals in the clinic is proposed, together with future approaches and research priorities.
Publication DOI: | https://doi.org/10.1111/all.14425 |
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Divisions: | College of Health & Life Sciences > School of Psychology College of Health & Life Sciences |
Additional Information: | This is the peer reviewed version of the following article: Agache, I., Akdis, C., Akdis, M., Canonica, G.W., Casale, T., Chivato, T., Corren, J., Chu, D.K., Del Giacco, S., Eiwegger, T., Flood, B., Firinu, D., Gern, J.E., Hamelmann, E., Hanania, N., Hernández‐Martín, I., Knibb, R., Mäkelä, M., Nair, P., O13037Mahony, L., Papadopoulos, N.G., Papi, A., Park, H.‐S., Pérez de Llano, L., Pfaar, O., Quirce, S., Sastre, J., Shamji, M., Schwarze, J., Palomares, O. and Jutel, M. (2020), EAACI Biologicals Guidelines – Recommendations for severe asthma. Allergy. Accepted Author Manuscript., which has been published in final form at https://doi.org/10.1111/all.14425. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving. |
Uncontrolled Keywords: | GRADE,biologicals,cost-effectiveness,guidelines,severe asthma,Immunology and Allergy,Immunology |
Publication ISSN: | 1398-9995 |
Last Modified: | 11 Oct 2024 07:22 |
Date Deposited: | 16 Jun 2020 13:49 |
Full Text Link: | |
Related URLs: |
https://onlinel ... .1111/all.14425
(Publisher URL) http://www.scop ... tnerID=8YFLogxK (Scopus URL) |
PURE Output Type: | Article |
Published Date: | 2021-01 |
Published Online Date: | 2020-06-02 |
Accepted Date: | 2020-06-01 |
Authors: |
Agache, Ioana
Akdis, Cezmi Akdis, Mubeccel Canonica, Giorgio Walter Casale, Thomas Chivato, Tomas Corren, Jonathan Chu, Derek K. Del Giacco, Stefano Eiwegger, Thomas Flood, Breda Firinu, Davide Gern, James E. Hamelmann, Eckard Hanania, Nicola Hernández‐martín, Irene Knibb, Rebeca ( 0000-0001-5561-0904) Mäkelä, Mika Nair, Parameswaran O13037mahony, Liam Papadopoulos, Nikolaos G. Papi, Alberto Park, Hae‐sim Pérez De Llano, Luis Pfaar, Oliver Quirce, Santiago Sastre, Joaquin Shamji, Mohamed Schwarze, Jurgen Palomares, Oscar Jutel, Marek |