Evaluation of intravoxel incoherent motion fitting methods in low-perfused tissue


Purpose To investigate the robustness of constrained and simultaneous intravoxel incoherent motion (IVIM) fitting methods and the estimated IVIM parameters (D, D* and f) for applications in brain and low‐perfused tissues. Materials and Methods Model data simulations relevant to brain and low‐perfused tumor tissues were computed to assess the accuracy, relative bias, and reproducibility (CV%) of the fitting methods in estimating the IVIM parameters. The simulations were performed at a series of signal‐to‐noise ratio (SNR) levels to assess the influence of noise on the fitting. Results The estimated IVIM parameters from model simulations were found significantly different (P < 0.05) using simultaneous and constrained fitting methods at low SNR. Higher accuracy and reproducibility were achieved with the constrained fitting method. Using this method, the mean error (%) for the estimated IVIM parameters at a clinically relevant SNR = 40 were D 0.35, D* 41.0 and f 4.55 for the tumor model and D 1.87, D* 2.48, and f 7.49 for the gray matter model. The most robust parameters were the IVIM‐D and IVIM‐f. The IVIM‐D* was increasingly overestimated at low perfusion. Conclusion A constrained IVIM fitting method provides more accurate and reproducible IVIM parameters in low‐perfused tissue compared with simultaneous fitting. Level of Evidence: 3

Publication DOI: https://doi.org/10.1002/jmri.25411
Divisions: College of Health & Life Sciences > School of Psychology
Additional Information: © 2016 The Authors Journal of Magnetic Resonance Imaging published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Publication ISSN: 1522-2586
Last Modified: 16 Apr 2024 07:19
Date Deposited: 20 May 2020 15:22
Full Text Link: http://www.scop ... tnerID=MN8TOARS
Related URLs: https://onlinel ... 1002/jmri.25411 (Publisher URL)
PURE Output Type: Article
Published Date: 2017-05
Published Online Date: 2016-08-22
Accepted Date: 2016-07-19
Authors: Meeus, E.M.
Novak, J. (ORCID Profile 0000-0001-5173-3608)
Withey, S.B.
Zarinabad, N.
Dehghani, H.
Peet, A.C.



Version: Published Version

License: Creative Commons Attribution

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