Rapid measurement of intravoxel incoherent motion (IVIM) derived perfusion fraction for clinical magnetic resonance imaging


Objective This study aimed to investigate the reliability of intravoxel incoherent motion (IVIM) model derived parameters D and f and their dependence on b value distributions with a rapid three b value acquisition protocol. Materials and methods Diffusion models for brain, kidney, and liver were assessed for bias, error, and reproducibility for the estimated IVIM parameters using b values 0 and 1000, and a b value between 200 and 900, at signal-to-noise ratios (SNR) 40, 55, and 80. Relative errors were used to estimate optimal b value distributions for each tissue scenario. Sixteen volunteers underwent brain DW-MRI, for which bias and coefficient of variation were determined in the grey matter. Results Bias had a large influence in the estimation of D and f for the low-perfused brain model, particularly at lower b values, with the same trends being confirmed by in vivo imaging. Significant differences were demonstrated in vivo for estimation of D (P = 0.029) and f (P < 0.001) with [300,1000] and [500,1000] distributions. The effect of bias was considerably lower for the high-perfused models. The optimal b value distributions were estimated to be brain500,1000, kidney300,1000, and liver200,1000. Conclusion IVIM parameters can be estimated using a rapid DW-MRI protocol, where the optimal b value distribution depends on tissue characteristics and compromise between bias and variability.

Publication DOI: https://doi.org/10.1007/s10334-017-0656-6
Divisions: College of Health & Life Sciences > School of Psychology
Publication ISSN: 0968-5243
Last Modified: 25 Mar 2024 18:50
Date Deposited: 20 May 2020 15:05
Full Text Link: http://www.scop ... tnerID=MN8TOARS
Related URLs: https://link.sp ... 0334-017-0656-6 (Publisher URL)
PURE Output Type: Article
Published Date: 2018
Published Online Date: 2017-10-26
Accepted Date: 2017-09-27
Authors: Meeus, E.M.
Novak, J. (ORCID Profile 0000-0001-5173-3608)
Dehghani, H.
Peet, A.C.



Version: Published Version

License: Creative Commons Attribution

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