The use of Stokes-Mueller polarimetry for assessment of amyloid-β progression in a mouse model of Alzheimer's disease

Abstract

Alzheimer's disease, being a major societal burden, demands improvement of current techniques for its treatment and diagnostics. Currently only autopsy histology is able to provide the definite diagnosis for Alzheimer's disease. However, the procedure is rather time consuming and costly. In the current study, we utilized Stokes and Mueller polarimetry techniques to screen for amyloid-β (Aβ) deposits in formalin-fixed, paraffin-embedded mouse brain tissue at different stages of Alzheimer's disease. The study has shown that the presence of Aβ plaques influences the properties of scattered polarized light. The Poincaré sphere was used as a graphical tool for the visualization of the alterations of the Stokes vector, obtained with Stokes polarimetry, whereas statistical moments were used for the analysis of depolarization distributions that were acquired with Mueller polarimetry. We demonstrate the sensitivity of the last component of the Stokes vector, the degree of polarization and high-order statistical moments of depolarization to the structural alterations in brain tissue, which correspond to the disease progression. The described approach has a potential to improve the existing pathology screening methods and facilitates Aβ detection in AD research.

Publication DOI: https://doi.org/10.1117/12.2550795
Divisions: College of Engineering & Physical Sciences > School of Engineering and Technology > Mechanical, Biomedical & Design
Additional Information: Copyright 2020 SPIE. One print or electronic copy may be made for personal use only. Systematic reproduction, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.
Event Title: Optical Biopsy XVIII: Toward Real-Time Spectroscopic Imaging and Diagnosis 2020
Event Type: Other
Event Dates: 2020-02-02 - 2020-02-05
Uncontrolled Keywords: Alzheimer's,Amyloid-ß plaque,Anisotropy,Depolarization,Scattering,Statistical analysis,Electronic, Optical and Magnetic Materials,Biomaterials,Atomic and Molecular Physics, and Optics,Radiology Nuclear Medicine and imaging
ISBN: 9781510632318
Full Text Link:
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
https://www.spi ... 795.short?SSO=1 (Publisher URL)
PURE Output Type: Conference contribution
Published Date: 2020-02-21
Accepted Date: 2020-01-01
Authors: Borovkova, Mariia
Bykov, Alexander
Popov, Alexey
Pierangelo, Angelo
Novikova, Tatiana
Pahnke, Jens
Meglinski, Igor (ORCID Profile 0000-0002-7613-8191)

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