Semyachkina-glushkovskaya, Oxana, Abdurashitov, Arkady, Dubrovsky, Alexander, Klimova, Maria, Agranovich, Ilana, Terskov, Andrey, Shirokov, Alexander, Vinnik, Valeria, Kuznecova, Anna, Lezhnev, Nikita, Blokhina, Inna, Shnitenkova, Anastassia, Tuchin, Valery, Rafailov, Edik and Kurths, Jurgen (2020). Photobiomodulation of lymphatic drainage and clearance: perspective strategy for augmentation of meningeal lymphatic functions. Biomedical Optics Express, 11 (2), pp. 725-734.
Abstract
There is a hypothesis that augmentation of the drainage and clearing function of the meningeal lymphatic vessels (MLVs) might be a promising therapeutic target for preventing neurological diseases. Here we investigate mechanisms of photobiomodulation (PBM, 1267 nm) of lymphatic drainage and clearance. Our results obtained at optical coherence tomography (OCT) give strong evidence that low PBM doses (5 and 10 J/cm2) stimulate drainage function of the lymphatic vessels via vasodilation (OCT data on the mesenteric lymphatics) and stimulation of lymphatic clearance (OCT data on clearance of gold nanorods from the brain) that was supported by confocal imaging of clearance of FITC-dextran from the cortex via MLVs. We assume that PBM-mediated relaxation of the lymphatic vessels can be possible mechanisms underlying increasing the permeability of the lymphatic endothelium that allows molecules transported by the lymphatic vessels and explain PBM stimulation of lymphatic drainage and clearance. These findings open new strategies for the stimulation of MLVs functions and non-pharmacological therapy of brain diseases.
Publication DOI: | https://doi.org/10.1364/BOE.383390 |
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Divisions: | College of Engineering & Physical Sciences > Aston Institute of Photonics Technology (AIPT) |
Additional Information: | © 2020 Optical Society of America under the terms of the OSA Open Access Publishing Agreement. Authors and readers may use, reuse, and build upon the article, or use it for text or data mining without asking prior permission from the publisher or the Author(s), as long as the purpose is non-commercial and appropriate attribution is maintained. Funding: Russian Science Foundation (17-15-01263, 18-15-00172, 19-15-00201). |
Uncontrolled Keywords: | Biotechnology,Atomic and Molecular Physics, and Optics |
Publication ISSN: | 2156-7085 |
Last Modified: | 11 Oct 2024 07:20 |
Date Deposited: | 15 Jan 2020 10:02 |
Full Text Link: | |
Related URLs: |
https://www.osa ... RI=boe-11-2-725
(Publisher URL) http://www.scop ... tnerID=8YFLogxK (Scopus URL) |
PURE Output Type: | Article |
Published Date: | 2020-02-01 |
Published Online Date: | 2020-01-10 |
Accepted Date: | 2020-01-05 |
Authors: |
Semyachkina-glushkovskaya, Oxana
Abdurashitov, Arkady Dubrovsky, Alexander Klimova, Maria Agranovich, Ilana Terskov, Andrey Shirokov, Alexander Vinnik, Valeria Kuznecova, Anna Lezhnev, Nikita Blokhina, Inna Shnitenkova, Anastassia Tuchin, Valery Rafailov, Edik ( 0000-0002-4152-0120) Kurths, Jurgen |