Dissecting the Antimicrobial Composition of Honey

Abstract

Honey is a complex sweet food stuff with well-established antimicrobial and antioxidant properties. It has been used for millennia in a variety of applications, but the most noteworthy include the treatment of surface wounds, burns and inflammation. A variety of substances in honey have been suggested as the key component to its antimicrobial potential; polyphenolic compounds, hydrogen peroxide, methylglyoxal and bee-defensin 1. These components vary greatly across honey samples due to botanical origin, geographical location and secretions from the bee. The use of medical grade honey in the treatment of surface wounds and burns has been seen to improve the healing process, reduce healing time, reduce scarring and prevent microbial contamination. Therefore, if medical grade honeys were to be included in clinical treatment, it would reduce the demand for antibiotic usage. In this review, we outline the constituents of honey and how they affect antibiotic potential in a clinical setting. By identifying the key components, we facilitate the development of an optimally antimicrobial honey by either synthetic or semisynthetic production methods.

Publication DOI: https://doi.org/10.3390/antibiotics8040251
Divisions: College of Health & Life Sciences > School of Biosciences
College of Health & Life Sciences
Additional Information: © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Uncontrolled Keywords: Antimicrobials,Bee-defensin 1,Honey,Hydrogen peroxide,Methylglyoxal,Wound treatment,Microbiology,Biochemistry,Pharmacology, Toxicology and Pharmaceutics(all),Microbiology (medical),Infectious Diseases,Pharmacology (medical)
Publication ISSN: 2079-6382
Full Text Link:
Related URLs: https://www.mdp ... 79-6382/8/4/251 (Publisher URL)
http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Review article
Published Date: 2019-12-05
Accepted Date: 2019-12-03
Authors: Nolan, Victoria C.
Harrison, James
Cox, Jonathan A. G. (ORCID Profile 0000-0001-5208-4056)

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