The Profiles and Correlates of Psychopathology in Adolescents and Adults with Williams, Fragile X and Prader-Willi Syndromes

Abstract

Psychopathology is prevalent in Williams (WS), fragile X (FXS) and Prader-Willi (PWS) syndromes. However, little is known about the potential correlates of psychopathology in these groups. A questionnaire study was completed by 111 caregivers of individuals with WS (n = 35); FXS (n = 50) and PWS (n = 26). Mean age was 26 years (range 12-57 years); 74 (67%) were male. Multiple regression analyses indicated that higher rates of health problems and sensory impairments predicted higher psychopathology in WS (p < .0001). In PWS, poorer adaptive ability predicted higher overall psychiatric disturbance (p = .001), generalised anxiety (p = .006) and hyperactivity (p = .003). There were no significant predictors in FXS. This study highlights dissociations in the potential risk markers of psychopathology between genetic syndromes. Implications for intervention are discussed.

Publication DOI: https://doi.org/10.1007/s10803-019-04317-1
Divisions: College of Health & Life Sciences > School of Psychology
Additional Information: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Uncontrolled Keywords: Correlates,Fragile X syndrome,Prader–Willi syndrome,Psychopathology,Williams syndrome,Developmental and Educational Psychology
Publication ISSN: 1573-3432
Full Text Link:
Related URLs: https://link.sp ... 803-019-04317-1 (Publisher URL)
http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2020-03-01
Published Online Date: 2019-12-04
Accepted Date: 2019-12-01
Authors: Royston, R
Oliver, C
Howlin, P
Dosse, A
Armitage, P
Moss, J
Waite, J (ORCID Profile 0000-0002-8676-3070)

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