Neuromodulators and long-term synaptic plasticity in learning and memory:A steered-glutamatergic perspective


The molecular pathways underlying the induction and maintenance of long-term synaptic plasticity have been extensively investigated revealing various mechanisms by which neurons control their synaptic strength. The dynamic nature of neuronal connections combined with plasticity-mediated long-lasting structural and functional alterations provide valuable insights into neuronal encoding processes as molecular substrates of not only learning and memory but potentially other sensory, motor and behavioural functions that reflect previous experience. However, one key element receiving little attention in the study of synaptic plasticity is the role of neuromodulators, which are known to orchestrate neuronal activity on brain-wide, network and synaptic scales. We aim to review current evidence on the mechanisms by which certain modulators, namely dopamine, acetylcholine, noradrenaline and serotonin, control synaptic plasticity induction through corresponding metabotropic receptors in a pathway-specific manner. Lastly, we propose that neuromodulators control plasticity outcomes through steering glutamatergic transmission, thereby gating its induction and maintenance.

Publication DOI:
Divisions: College of Health & Life Sciences > Aston Pharmacy School
College of Health & Life Sciences > Clinical and Systems Neuroscience
College of Health & Life Sciences
Additional Information: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
Uncontrolled Keywords: Astrocytes,GPCR,Learning,LTD,LTP,Memory,Neuromodulators,Synaptic plasticity,Neuroscience(all)
Publication ISSN: 2076-3425
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Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
https://www.mdp ... 6-3425/9/11/300 (Publisher URL)
PURE Output Type: Review article
Published Date: 2019-10-31
Accepted Date: 2019-10-29
Authors: Bazzari, Amjad H.
Parri, H. Rheinallt (ORCID Profile 0000-0002-1412-2688)



Version: Published Version

License: Creative Commons Attribution

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