Inhibiting dopamine reuptake blocks the induction of long-term potentiation and depression in the lateral entorhinal cortex of awake rats


Synaptic plasticity in olfactory inputs to the lateral entorhinal cortex may result in lasting changes in the processing of olfactory stimuli. Changes in dopaminergic tone can have strong effects on basal evoked synaptic responses in the superficial layers of the entorhinal cortex, and the current study investigated whether dopamine may modulate the induction of long-term potentiation (LTP) and depression (LTD) in piriform cortex inputs to layer II of the lateral entorhinal cortex in awake rats. Groups of animals were pretreated with either saline or the selective dopamine reuptake inhibitor GBR12909 prior to low or high frequency stimulation to induce LTD or LTP. In saline-treated groups, synaptic responses were potentiated to 122.4 ± 6.4% of baseline levels following LTP induction, and were reduced to 84.5 ± 4.9% following induction of LTD. Changes in synaptic responses were maintained for up to 60 min and returned to baseline levels within 24 h. In contrast, induction of both LTP and LTD was blocked in rats pretreated with GBR12909. Dopaminergic suppression of synaptic plasticity in the entorhinal cortex may serve to restrain activity-dependent plasticity during reward-relevant behavioral states or during processing of novel stimuli.

Publication DOI:
Divisions: College of Health & Life Sciences > Aston Pharmacy School
Funding Information: This research was funded by grants to D.A.C. and C.A.C. from the Natural Sciences and Engineering Research Council of Canada.
Additional Information: © 2007, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Uncontrolled Keywords: Memory,Olfaction,Parahippocampal,Piriform,Rat,Ventral tegmental area,Neuroscience(all)
Publication ISSN: 1872-7972
Last Modified: 17 Jun 2024 07:46
Date Deposited: 22 Nov 2019 10:06
Full Text Link:
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
https://www.sci ... 8956?via%3Dihub (Publisher URL)
PURE Output Type: Article
Published Date: 2007-10-09
Authors: Caruana, Douglas A. (ORCID Profile 0000-0002-8687-0263)
Reed, Sean J.
Sliz, Diane J.
Chapman, C. Andrew

Export / Share Citation


Additional statistics for this record