Caffeine-induced synaptic potentiation in hippocampal CA2 neurons


Caffeine enhances cognition, but even high non-physiological doses have modest effects on synapses. A 1 adenosine receptors (A 1 Rs) are antagonized by caffeine and are most highly enriched in hippocampal CA2, which has not been studied in this context. We found that physiological doses of caffeine in vivo or A 1 R antagonists in vitro induced robust, long-lasting potentiation of synaptic transmission in rat CA2 without affecting other regions of the hippocampus.

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Divisions: College of Health & Life Sciences > Aston Pharmacy School
College of Health & Life Sciences
Funding Information: We thank D. Armstrong and members of the Dudek laboratory for their input on the manuscript. This research was supported by the Intramural Research Program of the US National Institutes of Health, National Institute of Environmental Health Sciences (Z01 E
Additional Information: Copyright © 2011, Springer Nature
Uncontrolled Keywords: Neuroscience(all)
Publication ISSN: 1546-1726
Last Modified: 04 Mar 2024 08:36
Date Deposited: 20 Nov 2019 13:49
Full Text Link:
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
https://www.nat ... rticles/nn.2962 (Publisher URL)
PURE Output Type: Article
Published Date: 2012-01-01
Authors: Simons, Stephen B.
Caruana, Douglas A. (ORCID Profile 0000-0002-8687-0263)
Zhao, Meilan
Dudek, Serena M.



Version: Accepted Version

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