Simons, Stephen B., Caruana, Douglas A., Zhao, Meilan and Dudek, Serena M. (2012). Caffeine-induced synaptic potentiation in hippocampal CA2 neurons. Nature Neuroscience, 15 (1), pp. 23-25.
Abstract
Caffeine enhances cognition, but even high non-physiological doses have modest effects on synapses. A 1 adenosine receptors (A 1 Rs) are antagonized by caffeine and are most highly enriched in hippocampal CA2, which has not been studied in this context. We found that physiological doses of caffeine in vivo or A 1 R antagonists in vitro induced robust, long-lasting potentiation of synaptic transmission in rat CA2 without affecting other regions of the hippocampus.
Publication DOI: | https://doi.org/10.1038/nn.2962 |
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Divisions: | College of Health & Life Sciences > Aston Pharmacy School College of Health & Life Sciences |
Additional Information: | Copyright © 2011, Springer Nature |
Uncontrolled Keywords: | Neuroscience(all) |
Publication ISSN: | 1546-1726 |
Full Text Link: | |
Related URLs: |
http://www.scop ... tnerID=8YFLogxK
(Scopus URL) https://www.nat ... rticles/nn.2962 (Publisher URL) |
PURE Output Type: | Article |
Published Date: | 2012-01-01 |
Authors: |
Simons, Stephen B.
Caruana, Douglas A. ( ![]() Zhao, Meilan Dudek, Serena M. |