Simons, Stephen B., Caruana, Douglas A., Zhao, Meilan and Dudek, Serena M. (2012). Caffeine-induced synaptic potentiation in hippocampal CA2 neurons. Nature Neuroscience, 15 (1), pp. 23-25.
Abstract
Caffeine enhances cognition, but even high non-physiological doses have modest effects on synapses. A 1 adenosine receptors (A 1 Rs) are antagonized by caffeine and are most highly enriched in hippocampal CA2, which has not been studied in this context. We found that physiological doses of caffeine in vivo or A 1 R antagonists in vitro induced robust, long-lasting potentiation of synaptic transmission in rat CA2 without affecting other regions of the hippocampus.
| Publication DOI: | https://doi.org/10.1038/nn.2962 |
|---|---|
| Divisions: | College of Health & Life Sciences > Aston Pharmacy School College of Health & Life Sciences |
| Funding Information: | We thank D. Armstrong and members of the Dudek laboratory for their input on the manuscript. This research was supported by the Intramural Research Program of the US National Institutes of Health, National Institute of Environmental Health Sciences (Z01 E |
| Additional Information: | Copyright © 2011, Springer Nature |
| Uncontrolled Keywords: | General Neuroscience |
| Publication ISSN: | 1546-1726 |
| Last Modified: | 25 Apr 2025 07:08 |
| Date Deposited: | 20 Nov 2019 13:49 |
| Full Text Link: | |
| Related URLs: |
http://www.scop ... tnerID=8YFLogxK
(Scopus URL) https://www.nat ... rticles/nn.2962 (Publisher URL) |
PURE Output Type: | Article |
| Published Date: | 2012-01-01 |
| Authors: |
Simons, Stephen B.
Caruana, Douglas A. ( 
0000-0002-8687-0263)
Zhao, Meilan Dudek, Serena M. |