Caffeine-induced synaptic potentiation in hippocampal CA2 neurons


Caffeine enhances cognition, but even high non-physiological doses have modest effects on synapses. A 1 adenosine receptors (A 1 Rs) are antagonized by caffeine and are most highly enriched in hippocampal CA2, which has not been studied in this context. We found that physiological doses of caffeine in vivo or A 1 R antagonists in vitro induced robust, long-lasting potentiation of synaptic transmission in rat CA2 without affecting other regions of the hippocampus.

Publication DOI:
Divisions: College of Health & Life Sciences > Aston Pharmacy School
College of Health & Life Sciences
Additional Information: Copyright © 2011, Springer Nature
Uncontrolled Keywords: Neuroscience(all)
Publication ISSN: 1546-1726
Full Text Link:
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
https://www.nat ... rticles/nn.2962 (Publisher URL)
PURE Output Type: Article
Published Date: 2012-01-01
Authors: Simons, Stephen B.
Caruana, Douglas A. (ORCID Profile 0000-0002-8687-0263)
Zhao, Meilan
Dudek, Serena M.



Version: Accepted Version

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