DSD - An integrated, web-accessible database of dehydrogenase enzyme stereospecificities

Abstract

Background Dehydrogenase enzymes belong to the oxidoreductase class and utilise the coenzymes NAD and NADP. Stereo-selectivity is focused on the C4 hydrogen atoms of the nicotinamide ring of NAD(P). Depending upon which hydrogen is transferred at the C4 location, the enzyme is designated as A or B stereospecific. Description The Dehydrogenase Stereospecificity Database v1.0 (DSD) provides a compilation of enzyme stereochemical data, as sourced from the primary literature, in the form of a web-accessible database. There are two search engines, a menu driven search and a BLAST search. The entries are also linked to several external databases, including the NCBI and the Protein Data Bank, providing wide background information. The database is freely available online at: http://www.jenner.ac.uk/DSD/ webcite Conclusion DSD is a unique compilation available on-line for the first time which provides a key resource for the comparative analysis of reductase hydrogen transfer stereospecificity. As databases increasingly form the backbone of science, largely complete databases such as DSD, are a vital addition.

Publication DOI: https://doi.org/10.1186/1471-2105-6-283
Divisions: College of Health & Life Sciences > Aston Pharmacy School
College of Health & Life Sciences
Additional Information: © 2005 Toseland et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Publication ISSN: 1471-2407
Full Text Link:
Related URLs: https://bmcbioi ... 1471-2105-6-283 (Publisher URL)
PURE Output Type: Article
Published Date: 2005-11-30
Authors: Toseland, Christopher P.
McSparron, Helen M.
Flower, Darren R. (ORCID Profile 0000-0002-8542-7067)

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