The association between autism and schizophrenia spectrum disorders: A review of eight alternate models of co-occurrence

Abstract

Although now believed to be two distinct disorders, autism spectrum disorders (ASD) and schizophrenia spectrum disorders (SSD) share multiple phenotypic similarities and risk factors, and have been reported to co-occur at elevated rates. In this narrative review, we give a brief overview of the phenomenological, genetic, environmental, and imaging evidence for the overlap between ASD and SSD, highlighting similarities and areas of distinction. We examine eight possible alternate models of explanation for the association and comorbidity between the disorders, and set out a research agenda to test these models. Understanding how and why these disorders co-occur has important implications for diagnosis, treatment, and prognosis, as well as for developing fundamental aetiological models of the disorders.

Publication DOI: https://doi.org/10.1016/j.neubiorev.2015.04.012
Divisions: College of Health & Life Sciences > School of Psychology
College of Health & Life Sciences > Applied Health Research Group
College of Health & Life Sciences
Additional Information: © 2015, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
Publication ISSN: 1873-7528
Full Text Link:
Related URLs: https://www.sci ... 149763415001165 (Publisher URL)
PURE Output Type: Review article
Published Date: 2015-08-01
Published Online Date: 2015-05-05
Accepted Date: 2015-04-25
Authors: Chisholm, Katharine (ORCID Profile 0000-0002-0575-0789)
Lin, Ashleigh
Abu Akel, Ahmad
Wood, Stephen

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