Sanchez Aranguren, Lissette (2010). Deficiencia de vitamina D: ¿Factor de riesgo de síndrome metabólico?:Vitamina D y síndrome metabólico. Revista Medica de Chile, 138 (10), pp. 1312-1318.
Abstract
Vitamin D has an essential role in calcium metabolism and bone health. Vitamin D3 or cholecalciferol is synthesized from 7-dehydrocholesterol or provitamin D3, by sunlight ultraviolet radiation to the skin. 7-dehydrocholesterol is subsequently hydroxylated in the liver and then in the kidney to produce 1,25-(OH)2D3, the active metabolite that binds to specific receptors (VDR) in target tissues, mainly bone and intestine. Other tissues, such as the immune and cardiovascular system, have also VDR. Vitamin D deficiency can induce rickets in children and osteomalacia and osteoporosis in adults. A possible inverse association between vitamin D levels and the prevalence of metabolic syndrome has been proposed. Vitamin D deficiency increases the risk of type 1 diabetes, insulin resistance, and hypertension, key components of this syndrome. However, other studies have not confirmed this association. Further clinical and experimental studies are needed to ascertain the role of vitamin D in metabolic syndrome.
Publication DOI: | https://doi.org/10.4067/S0034-98872010001100017 |
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Divisions: | College of Health & Life Sciences > Aston Medical School College of Health & Life Sciences > Aston Medical School > Translational Medicine Research Group (TMRG) |
Additional Information: | Todo el contenido de esta revista, excepto dónde está identificado, está bajo una Licencia Creative Commons |
Last Modified: | 05 Dec 2024 08:17 |
Date Deposited: | 08 Oct 2019 12:11 | PURE Output Type: | Article |
Published Date: | 2010 |
Authors: |
Sanchez Aranguren, Lissette
(
0000-0002-4663-5752)
|