Neuroprotective effect of agmatine in mouse spinal cord injury model:Modulation by imidazoline receptors


Objective: The involvement of imidazoline receptors in the effect of agmatine was studied in locomotor recovery following experimental SCI (ESCI) in mice. Methods: ESCI was induced in mice using compression method. Locomotor function score (0-10) was measured on day 14 following ESCI. Results: Agmatine (2.5, 5, and 10 mg/kg) treatment through intraperitoneal route for 14 days following ESCI, dose-dependently improved the motor function score. Clonidine (0.1 mg/kg; imidazoline I1 receptor agonist) or moxonidine (0.5 mg/kg; I2 receptor agonist) treatment 15 min before agmatine (2.5 mg/kg) daily for 14 days, following ESCI, significantly potentiated the effect of per se agmatine. On the other hand, 15 min before treatment of efaroxan (1 mg/kg; imidazoline I1 receptor antagonist) or idazoxan (3 mg/kg; imidazoline I2 receptor antagonist) significantly blocked the motor function score of agmatine (10 mg/kg). Conclusion: These data suggest that imidazoline receptors may modulate the locomotor recovery following ESCI in agmatine treated mice, perhaps through I1/I2 receptors.

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Divisions: College of Health & Life Sciences > Aston Pharmacy School
College of Health & Life Sciences
Additional Information: This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
Uncontrolled Keywords: Agmatine,imidazoline receptors,locomotor recovery,motor function score,spinal cord injury,Biochemistry, Genetics and Molecular Biology(all)
Publication ISSN: 2229-7707
Last Modified: 29 Apr 2024 07:34
Date Deposited: 02 Oct 2019 10:47
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Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
http://www.jnsb ... st=Dixit;type=2 (Publisher URL)
PURE Output Type: Article
Published Date: 2018-07-01
Accepted Date: 2018-07-01
Authors: DIxit, Madhura
Upadhya, Manoj (ORCID Profile 0000-0002-2032-1472)
Taksande, Brijesh
Raut, Prachi
Umekar, Milind
Kotagale, Nandkishor

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