DJ-1 in Parkinson’s Disease: Clinical Insights and Therapeutic Perspectives

Abstract

Mutations in the protein DJ-1 cause autosomal recessive forms of Parkinson’s disease (PD) and oxidized DJ-1 is found in the brains of idiopathic PD individuals. While several functions have been ascribed to DJ-1 (most notably protection from oxidative stress), its contribution to PD pathogenesis is not yet clear. Here we provide an overview of the clinical research to date on DJ-1 and the current state of knowledge regarding DJ-1 characterization in the human brain. The relevance of DJ-1 as a PD biomarker is also discussed, as are studies exploring DJ-1 as a possible therapeutic target for PD and neurodegeneration.

Publication DOI: https://doi.org/10.3390/jcm8091377
Divisions: College of Health & Life Sciences > School of Biosciences
College of Health & Life Sciences
Additional Information: © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Funding: Wellcome Trust WT-ISSF.
Full Text Link:
Related URLs: https://www.mdp ... 7-0383/8/9/1377 (Publisher URL)
PURE Output Type: Review article
Published Date: 2019-09-03
Accepted Date: 2019-08-30
Authors: Repici, Mariaelena (ORCID Profile 0000-0002-9420-528X)
Giorgini, Flaviano

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