Repici, Mariaelena and Giorgini, Flaviano (2019). DJ-1 in Parkinson’s Disease: Clinical Insights and Therapeutic Perspectives. Journal of Clinical Medicine, 8 (9),
Abstract
Mutations in the protein DJ-1 cause autosomal recessive forms of Parkinson’s disease (PD) and oxidized DJ-1 is found in the brains of idiopathic PD individuals. While several functions have been ascribed to DJ-1 (most notably protection from oxidative stress), its contribution to PD pathogenesis is not yet clear. Here we provide an overview of the clinical research to date on DJ-1 and the current state of knowledge regarding DJ-1 characterization in the human brain. The relevance of DJ-1 as a PD biomarker is also discussed, as are studies exploring DJ-1 as a possible therapeutic target for PD and neurodegeneration.
| Publication DOI: | https://doi.org/10.3390/jcm8091377 |
|---|---|
| Divisions: | College of Health & Life Sciences > School of Biosciences College of Health & Life Sciences Aston University (General) |
| Additional Information: | © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Funding: Wellcome Trust WT-ISSF. |
| Last Modified: | 15 Nov 2024 08:10 |
| Date Deposited: | 09 Sep 2019 11:45 |
| Full Text Link: | |
| Related URLs: |
https://www.mdp ... 7-0383/8/9/1377
(Publisher URL) |
PURE Output Type: | Review article |
| Published Date: | 2019-09-03 |
| Accepted Date: | 2019-08-30 |
| Authors: |
Repici, Mariaelena
(
0000-0002-9420-528X)
Giorgini, Flaviano |
CORE (COnnecting REpositories)
CORE (COnnecting REpositories)