CD248 expression on mesenchymal stromal cells is required for post-natal and infection-dependent thymus remodelling and regeneration


The role of mesenchymal stromal cells (MSCs) in regulating immune responses in the thymus is currently unclear. Here we report the existence and role of a MSC population in the thymus that expresses the pericyte and MSC marker CD248 (endosialin). We show using a CD248-deficient mouse model, that CD248 expression on these cells is required for full post-natal thymus development and regeneration post-Salmonella infection. In CD248 -/- mice the thymus is hypocellular and regeneration is poorer, with significant loss of all thymocyte populations. This identifies the requirement of CD248 to maintain optimal thymic cellularity post-partum and infection.

Publication DOI:
Divisions: College of Health & Life Sciences
College of Health & Life Sciences > School of Biosciences
Additional Information: ©2015 The Authors. Published by FEBS Press and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
Uncontrolled Keywords: CD248,Endosialin,MSC,Thymus,Biochemistry, Genetics and Molecular Biology(all)
Publication ISSN: 2211-5463
Last Modified: 08 Jan 2024 09:16
Date Deposited: 02 Sep 2019 14:20
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Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
https://febs.on ... fob.2012.07.003 (Publisher URL)
PURE Output Type: Article
Published Date: 2012-07-20
Authors: Lax, Siân
Ross, Ewan A. (ORCID Profile 0000-0001-5733-9361)
White, Andrea
Marshall, Jennifer L.
Jenkinson, William E.
Isacke, Clare M.
Huso, David L.
Cunningham, Adam F.
Anderson, Graham
Buckley, Christopher D.

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