Mechanisms governing the reactivation-dependent destabilization of memories and their role in extinction


The extinction of learned associations has traditionally been considered to involve new learning, which competes with the original memory for control over behavior. However, a recent resurgence of interest in reactivation-dependent amnesia has revealed that the retrieval of fear-related memory (with what is essentially a brief extinction session) can result in its destabilization. This review discusses some of the cellular and molecular mechanisms that are involved in the destabilization of a memory following its reactivation and/or extinction, and investigates the evidence that extinction may involve both new learning as well as a partial destabilization-induced erasure of the original memory trace.

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Divisions: College of Health & Life Sciences > School of Biosciences
College of Health & Life Sciences
Additional Information: © 2013 Flavell, Lambert, Winters and Bredy. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Publication ISSN: 1662-5153
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Related URLs: http://journal. ... .00214/abstract (Publisher URL)
PURE Output Type: Article
Published Date: 2013-12-26
Authors: Flavell, Charlotte R. (ORCID Profile 0000-0003-0345-0237)
Lambert, Elliot A.
Winters, Boyer D.
Bredy, Timothy W.



Version: Published Version

License: Creative Commons Attribution

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