Detection and characterisation of bone destruction in murine rheumatoid arthritis using statistical shape models


Rheumatoid arthritis (RA) is an autoimmune disease in which chronic inflammation of the synovial joints can lead to destruction of cartilage and bone. Pre-clinical studies attempt to uncover the underlying causes by emulating the disease in genetically different mouse strains and characterising the nature and severity of bone shape changes as indicators of pathology. This paper presents a fully automated method for obtaining quantitative measurements of bone destruction from volumetric micro-CT images of a mouse hind paw. A statistical model of normal bone morphology derived from a training set of healthy examples serves as a template against which a given pathological sample is compared. Abnormalities in bone shapes are identified as deviations from the model statistics, characterised in terms of type (erosion / formation) and quantified in terms of severity (percentage affected bone area). The colour-coded magnitudes of the deviations superimposed on a three-dimensional rendering of the paw show at a glance the severity of malformations for the individual bones and joints. With quantitative data it is possible to derive population statistics characterising differences in bone malformations for different mouse strains and in different anatomical regions. The method was applied to data acquired from three different mouse strains. The derived quantitative indicators of bone destruction have shown agreement both with the subjective visual scores and with the previous biological findings. This suggests that pathological bone shape changes can be usefully and objectively identified as deviations from the model statistics.

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Divisions: College of Health & Life Sciences > School of Biosciences
College of Health & Life Sciences
Funding Information: This work was supported by Arthritis Research UK (Arthritis Research UK programme grant (19791) and an Arthritis Research UK Foundation Fellowship (AJN)); and through the Engineering and Physical Sciences Research Council studentship (JMB) from the Physic
Additional Information: © 2017, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Uncontrolled Keywords: Murine models,Quantification of bone destruction,Rheumatoid arthritis,Statistical shape models,Radiological and Ultrasound Technology,Radiology Nuclear Medicine and imaging,Computer Vision and Pattern Recognition,Health Informatics,Computer Graphics and Computer-Aided Design
Publication ISSN: 1361-8423
Last Modified: 24 May 2024 07:15
Date Deposited: 30 Aug 2019 09:05
Full Text Link: https://researc ... a6cb49b73).html
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2017-08-01
Published Online Date: 2017-05-23
Accepted Date: 2017-05-22
Authors: Brown, James M.
Ross, Ewan (ORCID Profile 0000-0001-5733-9361)
Desanti, Guillaume
Saghir, Atif
Clark, Andy
Buckley, Chris
Filer, Andrew
Naylor, Amy
Claridge, Ela

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