Postretrieval Relearning Strengthens Hippocampal Memories via Destabilization and Reconsolidation.


Memory reconsolidation is hypothesized to be a mechanism by which memories can be updated with new information. Such updating has previously been shown to weaken memory expression or change the nature of the memory. Here we demonstrate that retrieval-induced memory destabilization also allows that memory to be strengthened by additional learning. We show that for rodent contextual fear memories, this retrieval conditioning effect is observed only when conditioning occurs within a specific temporal window opened by retrieval. Moreover, it necessitates hippocampal protein degradation at the proteasome and engages hippocampal Zif268 protein expression, both of which are established mechanisms of memory destabilization-reconsolidation. We also demonstrate a conceptually analogous pattern of results in human visual paired-associate learning. Retrieval-relearning strengthens memory performance, again only when relearning occurs within the temporal window of memory reconsolidation. These findings link retrieval-mediated learning in humans to the reconsolidation literature, and have potential implications both for the understanding of endogenous memory gains and strategies to boost weakly learned memories.

Publication DOI:
Divisions: College of Health & Life Sciences > School of Biosciences
College of Health & Life Sciences
Additional Information: Copyright © 2019 the authors. Articles are released under a Creative Commons Attribution License after a 6 months embargo
Uncontrolled Keywords: Destabilization,Fear conditioning,Memory,Reconsolidation,Retrieval,Neuroscience(all)
Publication ISSN: 1529-2401
Full Text Link:
Related URLs: https://www.jne ... ntent/39/6/1109 (Publisher URL)
http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2019-02-06
Published Online Date: 2018-12-26
Accepted Date: 2018-12-12
Authors: Rong Tay, Kai
Law, Charlotte (ORCID Profile 0000-0003-0345-0237)
Cassini, Lindsey F.
Wimber, Maria
Lee, Jonathan



Version: Published Version

License: Creative Commons Attribution

| Preview

Export / Share Citation


Additional statistics for this record