On the transition from reconsolidation to extinction of contextual fear memories.


Retrieval of an associative memory can lead to different phenomena. Brief reexposure sessions tend to trigger reconsolidation, whereas more extended ones trigger extinction. In appetitive and fear cued Pavlovian memories, an intermediate "null point" period has been observed where neither process seems to be engaged. Here we investigated whether this phenomenon extends to contextual fear memory. Adult rats were subjected to a contextual fear conditioning paradigm, reexposed to the context 2 d later for 3, 5, 10, 20, or 30 min, with immediate injections of MK-801 or saline following reexposure, and tested on the following day. We observed a significant effect of MK-801 with the 3- and 30-min sessions, impairing reconsolidation and extinction, respectively. However, it did not have significant effects with 5-, 10-, or 20-min sessions, even though freezing decreased from reexposure to test. Further analyses indicated that this is not likely to be due to a variable transition point at the population level. In conclusion, the results show that in contextual fear memories there is a genuine "null point" between the parameters that induce reconsolidation and extinction, as defined by the effects of MK-801, although NMDA receptor-independent decreases in freezing can still occur in these conditions.

Publication DOI: https://doi.org/10.1101/lm.045724.117
Divisions: College of Health & Life Sciences > School of Biosciences
College of Health & Life Sciences
Additional Information: © 2017 Cassini et al.; Published by Cold Spring Harbor Laboratory Press This article, published in Learning & Memory, is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4.0/.
Publication ISSN: 1549-5485
Full Text Link:
Related URLs: http://learnmem ... 2.full.pdf+html (Publisher URL)
PURE Output Type: Article
Published Date: 2017-08-16
Accepted Date: 2017-06-29
Authors: Cassini, Lindsey F.
Law, Charlotte (ORCID Profile 0000-0003-0345-0237)
Amaral, Olavo B.
Lee, Jonathan



Version: Published Version

License: Creative Commons Attribution

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