Characterization and cytotoxicity studies of thiol-modified polystyrene microbeads doped with [(Mo6X8)(NO3)6]2- (X=Cl, Br, I)

Abstract

Halide octahedral molybdenum clusters [(Mo6X8)L6]n- possess luminescence properties that are highly promising for biological applications. These properties are rather dependent on the nature of both the inner ligands X (i.e. Cl, Br, or I) and the apical organic or inorganic ligands L. Herein, the luminescence properties and the toxicity of thiol-modified polystyrene microbeads (PS-SH) doped with [(Mo6X8)(NO3)6]2- (X=Cl, Br, I) were studied and evaluated using human epidermoid larynx carcinoma (Hep2) cell cultures. According to our data, the photoluminescence quantum yield of (Mo6I8)@PS-SH is significantly higher (0.04) than that of (Mo6Cl8)@PS-SH (6Br8)@PS-SH (6X8)@PS-SH showed that all three types of doped microbeads had no significant effect on the viability and proliferation of the cells.

Publication DOI: https://doi.org/10.1002/pat.3749
Divisions: College of Engineering & Physical Sciences > School of Infrastructure and Sustainable Engineering > Chemical Engineering & Applied Chemistry
College of Engineering & Physical Sciences > Aston Institute of Materials Research (AIMR)
College of Engineering & Physical Sciences > School of Informatics and Digital Engineering > Mathematics
College of Engineering & Physical Sciences
Additional Information: This is the peer reviewed version of the following article: Vorotnikova, N. A., Efremova, O. A., Tsygankova, A. R., Brylev, K. A., Edeleva, M. V., Kurskaya, O. G., ... Shestopalov, M. A. (2016). Characterization and cytotoxicity studies of thiol-modified polystyrene microbeads doped with [(Mo6X8)(NO3)6]2- (X=Cl, Br, I). Polymers for advanced technologies, Early view., which has been published in final form at http://dx.doi.org/10.1002/pat.3749. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. Funding: Russian Science Foundation (14-14-00192); Royal Society (IE140281); and FP7 Marie Curie Inter-European Fellowship (327440)
Uncontrolled Keywords: cytotoxicity,molybdenum cluster complex,photoluminescence,polystyrene microbeads,Polymers and Plastics
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Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
https://onlinel ... 0.1002/pat.3749 (Publisher URL)
PURE Output Type: Article
Published Date: 2016-06-13
Published Online Date: 2016-01-11
Accepted Date: 2015-12-05
Submitted Date: 2015-10-08
Authors: Vorotnikova, Natalya A.
Efremova, Olga A.
Tsygankova, Alphiya R.
Brylev, Konstantin A.
Edeleva, Mariya V.
Kurskaya, Olga G.
Sutherland, Andrew J. (ORCID Profile 0000-0003-3651-1809)
Shestopalov, Alexandr M.
Mironov, Yuri V.
Shestopalov, Michael A.

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