Stem cell-derived astrocytes:are they physiologically credible?


Astrocytes are now increasingly acknowledged as having fundamental and sophisticated roles in brain function and dysfunction. Unravelling the complex mechanisms that underlie human brain astrocyte-neuron interactions is therefore an essential step on the way to understanding how the brain operates. Insights into astrocyte function to date, have almost exclusively been derived from studies conducted using murine or rodent models. Whilst these have led to significant discoveries, preliminary work with human astrocytes has revealed a hitherto unknown range of astrocyte types with potentially greater functional complexity and increased neuronal interaction with respect to animal astrocytes. It is becoming apparent, therefore, that many important functions of astrocytes will only be discovered by direct physiological interrogation of human astrocytes. Recent advancements in the field of stem cell biology have provided a source of human based models. These will provide a platform to facilitate our understanding of normal astrocyte functions as well as their role in CNS pathology. A number of recent studies have demonstrated that stem cell derived astrocytes exhibit a range of properties, suggesting that they may be functionally equivalent to their in vivo counterparts. Further validation against in vivo models will ultimately confirm the future utility of these stem-cell based approaches in fulfilling the need for human- based cellular models for basic and clinical research. In this review we discuss the roles of astrocytes in the brain and highlight the extent to which human stem cell derived astrocytes have demonstrated functional activities that are equivalent to that observed in vivo.

Publication DOI:
Divisions: College of Health & Life Sciences > School of Biosciences
College of Health & Life Sciences
College of Health & Life Sciences > Chronic and Communicable Conditions
College of Health & Life Sciences > Clinical and Systems Neuroscience
College of Health & Life Sciences > School of Biosciences > Cell & Tissue Biomedical Research
College of Health & Life Sciences > Aston Pharmacy School
College of Health & Life Sciences > School of Biosciences > Cellular and Molecular Biomedicine
Additional Information: This is the peer reviewed version of the following article: Hill, E., Nagel, D., Parri, R., & Coleman, M. (2016). Stem cell-derived astrocytes: are they physiologically credible? Journal of Physiology, 594(22), 6595-6606, which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. Funding: Alzheimer’s research UK (ART-PPG2009B-3 and ART-PG2007B-6) and BBSRC (BB/H008527/1).
Uncontrolled Keywords: stem cells,astrocytes,neurons,metabolism,gliotransmission,Physiology
Publication ISSN: 1469-7793
Last Modified: 17 May 2024 07:12
Date Deposited: 19 Aug 2019 09:46
Full Text Link: http://onlineli ... 270658/abstract
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Book/Film/Article review
Published Date: 2016-11-15
Published Online Date: 2015-12-04
Accepted Date: 2015-11-28
Submitted Date: 2015-08-13
Authors: Hill, Eric (ORCID Profile 0000-0002-9419-1500)
Nagel, David (ORCID Profile 0000-0002-9055-1775)
Parri, Rheinallt (ORCID Profile 0000-0002-1412-2688)
Coleman, Michael (ORCID Profile 0000-0002-5510-6852)



Version: Accepted Version

| Preview

Export / Share Citation


Additional statistics for this record