Apoptotic cell-derived extracellular vesicles: structure-function relationships.


Apoptosis is an essential process for normal physiology and plays a key role in the resolution of inflammation. Clearance of apoptotic cells (ACs) involves complex signalling between phagocytic cells, ACs, and the extracellular vesicles (EVs) they produce. Here, we discuss apoptotic cell-derived extracellular vesicles (ACdEVs) and how their structure relates to their function in AC clearance and the control of inflammation, focussing on the ACdEV proteome. We review the current knowledge, ongoing work and future directions for research in this field.

Publication DOI: https://doi.org/10.1042/BST20180080
Divisions: College of Health & Life Sciences > School of Biosciences
College of Health & Life Sciences
College of Health & Life Sciences > School of Biosciences > Cell & Tissue Biomedical Research
College of Health & Life Sciences > Chronic and Communicable Conditions
College of Health & Life Sciences > School of Biosciences > Cellular and Molecular Biomedicine
Additional Information: © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
Uncontrolled Keywords: extracellular vesicles,macrophages,phagocytosis,Biochemistry
Publication ISSN: 1470-8752
Last Modified: 11 Mar 2024 08:27
Date Deposited: 19 Aug 2019 09:39
Full Text Link:
Related URLs: http://www.bioc ... 0.full-text.pdf (Publisher URL)
http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Review article
Published Date: 2019-04-30
Published Online Date: 2019-04-05
Accepted Date: 2019-04-01
Authors: Grant, Lois
Milic, Ivana (ORCID Profile 0000-0001-7531-7561)
Devitt, Andrew (ORCID Profile 0000-0002-4651-6761)



Version: Accepted Version

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