Short-term effects of very low dose cadmium feeding on copper, manganese and iron homeostasis:A gastropod perspective


The available information on the interplay between low-dose cadmium intake and copper, manganese, and iron homeostasis in invertebrates is limited. We have currently studied the accumulation of these trace metals in the hepatopancreas of adult snails, Cantareus aspersus, following 14 and 28 days of exposure to low doses of dietary cadmium, up to 1 mg/kg dw (dry weight). The cadmium dose, but not the duration of exposure, had a significant effect on hepatopancreas copper deposition, the values being significantly elevated compared to controls. A significant peak in manganese levels at 14 days was found in snails administered the lowest cadmium dose. These increases occurred even in the absence of cadmium increase in the hepatopancreas. Our data suggest that low dose cadmium feeding can produce a transient disturbance in hepatopancreas copper and manganese homeostasis. Such responses may serve as early biomarkers of physiological changes occurring during the initial stages of cadmium intoxication.

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Divisions: College of Health & Life Sciences > Aston Pharmacy School
College of Health & Life Sciences
College of Health & Life Sciences > Chronic and Communicable Conditions
College of Health & Life Sciences > School of Biosciences > Cellular and Molecular Biomedicine
Additional Information: © 2018, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Uncontrolled Keywords: cadmium,copper,manganese,iron,dietary exposure,land snails
Publication ISSN: 1872-7077
Last Modified: 22 Apr 2024 07:21
Date Deposited: 19 Aug 2019 09:39
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Related URLs: https://linking ... 382668918305453 (Publisher URL)
PURE Output Type: Article
Published Date: 2019-01
Published Online Date: 2018-10-28
Accepted Date: 2018-10-24
Authors: Nica, Dragos V.
Draghici, George A.
Andrica, Florina-maria
Popescu, Sofia
Coricovac, Dorina E.
Dehelean, Cristina A.
Gergen, Iosif I.
Kovatsi, Leda
Coleman, Michael D. (ORCID Profile 0000-0002-5510-6852)
Tsatsakis, Aristidis

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