Developing accurate models of the human airways


Objectives Particle delivery to the airways is an attractive prospect for many potential therapeutics, including vaccines. Developing strategies for inhalation of particles provides a targeted, controlled and non-invasive delivery route but, as with all novel therapeutics, in vitro and in vivo testing are needed prior to clinical use. Whilst advanced vaccine testing demands the use of animal models to address safety issues, the production of robust in vitro cellular models would take account of the ethical framework known as the 3Rs (Replacement, Reduction and Refinement of animal use), by permitting initial screening of potential candidates prior to animal use. There is thus a need for relevant, realistic in vitro models of the human airways. Key findings Our laboratory has designed and characterised a multi-cellular model of human airways that takes account of the conditions in the airways and recapitulates many salient features, including the epithelial barrier and mucus secretion. Summary Our human pulmonary models recreate many of the obstacles to successful pulmonary delivery of particles and therefore represent a valid test platform for screening compounds and delivery systems.

Publication DOI:
Divisions: College of Health & Life Sciences > School of Biosciences
College of Health & Life Sciences > Chronic and Communicable Conditions
College of Health & Life Sciences
College of Health & Life Sciences > Aston Pharmacy School
College of Health & Life Sciences > School of Biosciences > Cellular and Molecular Biomedicine
College of Health & Life Sciences > School of Biosciences > Cell & Tissue Biomedical Research
Additional Information: This is the peer reviewed version of the following article: Marshall, LJ, Oguejiofor, W, Willetts, RS, Griffiths, HR & Devitt, A 2015, 'Developing accurate models of the human airways' Journal of pharmacy and pharmacology, vol 67, no. 3, pp. 464-472, which has been published in final form at
Uncontrolled Keywords: cellular drug uptake and absorption,drug delivery to specific tissues,Pharmacology,Pharmaceutical Science
Publication ISSN: 2042-7158
Last Modified: 27 Jun 2024 08:26
Date Deposited: 19 Aug 2019 09:36
Full Text Link: http://onlineli ... .12340/abstract
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2015
Published Online Date: 2014-12-31
Authors: Marshall, Lindsay J. (ORCID Profile 0000-0001-7281-7974)
Oguejiofor, Wilson
Willetts, Rachel S.
Griffiths, Helen R. (ORCID Profile 0000-0002-2666-2147)
Devitt, Andrew (ORCID Profile 0000-0002-4651-6761)



Version: Accepted Version

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