Abnormal retinal vascular reactivity in individuals with impaired glucose tolerance:a preliminary study


To investigate the relationship between vascular function parameters measured at the retinal and systemic level and known markers for cardiovascular risk in patients with impaired glucose tolerance (IGT). Sixty age- and gender- matched White-European adults (30 IGT and 30 normal glucose tolerance -NGT) were recruited for the study. Fasting plasma glucose, lipids and 24-hour blood pressure (BP) was measured in all subjects. Systemic vascular and endothelial function was assessed using carotid-artery intimal media thickness (cIMT) and flow mediated dilation (FMD). Retinal vascular reactivity was assessed by the Dynamic Retinal Vessel Analyser (DVA). Additionally, blood glutathione (GSH, GSSG and tGSH) and plasma von-Willebrand (vWF) factor levels were also measured. Individuals with IGT demonstrated higher BP values (p<0.001), fasting TG and TG:HDL ratios (p<0.001) than NGT subjects. Furthermore, Total:HDL-C ratios and Framingham scores were raised (p=0.010 and p<0.001 respectively). Blood glutathione levels (GSH, GSSG and tGSH) were lower (p<0.001, p=0.039 and p<0.001 respectively) while plasma vWF was increased (p=0.014) in IGT subjects compared to controls. IGT individuals also demonstrated higher IMT in right and left carotid arteries (p=0.017 and p=0.005, respectively) alongside larger brachial artery diameter (p=0.015), lower FMD% (p=0.026) and GTN induced dilation (GID) (p=0.012) than healthy controls. At the retinal arterial level, the IGT subjects showed higher baseline fluctuations (BDF) (p=0.026), longer reaction time (RT) (p=0.032) and reduced baseline-corrected flicker response (bFR) (p=0.045). In IGT subjects retinal BDF correlated with and Total:HDL (p= 0.003) and HDL-C (p= 0.004). Arterial RT also correlated with FMD (p=0.017) in IGT but not NGT subjects. In IGT individuals there is a relationship between macro- and microvascular function, as well as a direct correlation between the observed retinal microcirculatory changes and established plasma markers for CVD. Multifactorial preventive interventions to decrease vascular risk in these individuals should be considered.

Publication DOI: https://doi.org/10.1167/iovs.12-9512
Divisions: College of Health & Life Sciences > School of Optometry > Optometry
College of Health & Life Sciences > School of Biosciences
College of Health & Life Sciences > Chronic and Communicable Conditions
College of Health & Life Sciences
College of Health & Life Sciences > School of Optometry > Optometry & Vision Science Research Group (OVSRG)
College of Health & Life Sciences > School of Optometry > Vision, Hearing and Language
Additional Information: Copyright 2012 The Association for Research in Vision and Ophthalmology, Inc
Uncontrolled Keywords: retinal vascular function,diabetes risk,cardiovascular risk,Ophthalmology,Sensory Systems,Cellular and Molecular Neuroscience
Publication ISSN: 1552-5783
Last Modified: 09 May 2024 16:23
Date Deposited: 19 Aug 2019 09:09
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Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
http://iovs.arv ... ticleid=2165832 (Publisher URL)
PURE Output Type: Article
Published Date: 2012-08
Published Online Date: 2012-06-28
Authors: Patel, Sunni R.
Bellary, Srikanth (ORCID Profile 0000-0002-5924-5278)
Qin, Lu
Balanos, George M.
McIntyre, David
Gherghel, Doina (ORCID Profile 0000-0001-9439-5573)

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