Dimitrov, Ivan, Garnev, Panayot, Flower, Darren R and Doytchinova, Irini (2010). EpiTOP—a proteochemometric tool for MHC class II binding prediction. Bioinformatics, 26 (16), pp. 2066-8.
Abstract
Motivation: T-cell epitope identification is a critical immunoinformatic problem within vaccine design. To be an epitope, a peptide must bind an MHC protein. Results: Here, we present EpiTOP, the first server predicting MHC class II binding based on proteochemometrics, a QSAR approach for ligands binding to several related proteins. EpiTOP uses a quantitative matrix to predict binding to 12 HLA-DRB1 alleles. It identifies 89% of known epitopes within the top 20% of predicted binders, reducing laboratory labour, materials and time by 80%. EpiTOP is easy to use, gives comprehensive quantitative predictions and will be expanded and updated with new quantitative matrices over time.
Publication DOI: | https://doi.org/10.1093/bioinformatics/btq324 |
---|---|
Divisions: | College of Health & Life Sciences > Aston Pharmacy School College of Health & Life Sciences College of Health & Life Sciences > Chronic and Communicable Conditions |
Additional Information: | This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Bioinformatics following peer review. The definitive publisher-authenticated version Dimitrov, I, Garnev, P, Flower, DR & Doytchinova, I 2010, 'EpiTOP—a proteochemometric tool for MHC class II binding prediction', Bioinformatics (Oxford, England), vol 26, no. 16, pp. 2066-8. is available online at:http://bioinformatics.oxfordjournals.org/content/26/16/2066. |
Uncontrolled Keywords: | alleles,T-lymphocyte epitopes,HLA-DR antigens,HLA-DRB1 chains,histocompatibility antigens class II,ligands,peptides,software,Biochemistry,Molecular Biology,Computational Theory and Mathematics,Computer Science Applications,Computational Mathematics,Statistics and Probability,General Medicine |
Publication ISSN: | 1367-4803 |
Last Modified: | 03 Dec 2024 08:05 |
Date Deposited: | 19 Aug 2019 08:52 |
Full Text Link: |
http://bioinfor ... tent/26/16/2066 |
Related URLs: |
http://www.scop ... tnerID=8YFLogxK
(Scopus URL) |
PURE Output Type: | Article |
Published Date: | 2010-08-15 |
Published Online Date: | 2010-06-23 |
Authors: |
Dimitrov, Ivan
Garnev, Panayot Flower, Darren R ( 0000-0002-8542-7067) Doytchinova, Irini |