Wearable sensor system for multipoint measurements of blood perfusion: pilot studies in patients with diabetes mellitus


The growing interest in the development of new wearable electronic devices for mobile healthcare provides great opportunities for the development of methods for assessing blood perfusion in this direction. Laser Doppler flowmetry (LDF) is one of the promising methods. A fine analysis of capillary blood ow structure and rhythm in the time and frequency domains, coupled with a new possibility of round-the-clock monitoring can provide valuable diagnostic information about the state of microvascular blood ow. In this study, wearable implementation of laser Doppler flowmetry was utilised for microcirculatory function assessment in patients with diabetes and healthy controls of two distinct age groups. Four wearable laser Doppler flowmetry monitors were used for the analysis of blood microcirculation. Thirty-seven healthy volunteers and 18 patients with type 2 diabetes mellitus participated in the study. The results of the studies have shown that the average perfusion differs between healthy volunteers of distinct age groups and between healthy volunteers of the younger age group and patients with diabetes mellitus. It was noted that the average level of perfusion measured on the wrist in the two groups of healthy volunteers has no statistically significant differences found in similar measurements on the fingertips. The wearable implementation of LDF can become a truly new diagnostic interface to monitor cardiovascular parameters, which could be of interest for diagnostics of conditions associated with microvascular disorders.

Publication DOI: https://doi.org/10.1117/12.2526966
Divisions: College of Engineering & Physical Sciences > Aston Institute of Photonics Technology (AIPT)
College of Engineering & Physical Sciences
Funding Information: This study was funded by the Russian Science Foundation (the research project 18-79-00237). Evgeny Zherebtsov kindly acknowledges for personal support from grant of Academy of Finland No.318281 (data processing).
Additional Information: Copyright 2019 SPIE. One print or electronic copy may be made for personal use only. Systematic reproduction, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited. Funding: Russian Science Foundation (the research project 18-79-00237), grant of Academy of Finland No.318281
Uncontrolled Keywords: Ageing,Blood flow,Diabetes mellitus,Laser Doppler owmetry,Wearable blood perfusion sensor,Electronic, Optical and Magnetic Materials,Biomaterials,Atomic and Molecular Physics, and Optics,Radiology Nuclear Medicine and imaging
Publication ISSN: 1996-756X
Last Modified: 13 May 2024 07:26
Date Deposited: 31 Jul 2019 09:30
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Related URLs: https://www.spi ... 12.2526966.full (Publisher URL)
http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Conference article
Published Date: 2019-07-22
Accepted Date: 2019-06-01
Authors: Zherebtsov, Evgeny A. (ORCID Profile 0000-0002-3635-1430)
Zharkikh, Elena V.
Kozlov, Igor O.
Loktionova, Yulia I.
Zherebtsova, Angelina I.
Rafailov, Ilya E.
Sokolovski, Sergei G. (ORCID Profile 0000-0001-7445-7204)
Sidorov, Victor V.
Dunaev, Andrey V.
Rafailov, Edik U. (ORCID Profile 0000-0002-4152-0120)



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