Enhanced diagnostic of skin conditions by polarized laser speckles:Phantom studies and computer modeling

Abstract

The incidence of the skin melanoma, the most commonly fatal form of skin cancer, is increasing faster than any other potentially preventable cancer. Clinical practice is currently hampered by the lack of the ability to rapidly screen the functional and morphological properties of tissues. In our previous study we show that the quantification of scattered laser light polarization provides a useful metrics for diagnostics of the malignant melanoma. In this study we exploit whether the image speckle could improve skin cancer diagnostic in comparison with the previously used free-space speckle. The study includes skin phantom measurements and computer modeling. To characterize the depolarization of light we measure the spatial distribution of speckle patterns and analyse their depolarization ratio taken into account radial symmetry. We examine the dependences of depolarization ratio vs. roughness for phantoms which optical properties are of the order of skin lesions. We demonstrate that the variation in bulk optical properties initiates the assessable changes in the depolarization ratio. We show that image speckle differentiates phantoms significantly better than free-space speckle. The results of experimental measurements are compared with the results of Monte Carlo simulation.

Publication DOI: https://doi.org/10.1117/12.2040192
Divisions: College of Engineering & Physical Sciences > School of Engineering and Technology > Mechanical, Biomedical & Design
College of Engineering & Physical Sciences
Additional Information: Copyright 2014 SPIE. One print or electronic copy may be made for personal use only. Systematic reproduction, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.
Uncontrolled Keywords: Depolarization ratio,Laser speckle imaging,Melanoma,Monte Carlo modelling,Polarization,Skin cancer,Skin phantom,Surface roughness,Electronic, Optical and Magnetic Materials,Biomaterials,Atomic and Molecular Physics, and Optics,Radiology Nuclear Medicine and imaging
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Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
https://www.spi ... 12.2040192.full (Publisher URL)
PURE Output Type: Conference article
Published Date: 2014-03-04
Authors: Tchvialeva, Lioudmila
Lee, Tim K.
Markhvida, Igor
Zeng, Haishan
Doronin, Alexander
Meglinski, Igor (ORCID Profile 0000-0002-7613-8191)

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